NPS-1034-Standard-生命科学试剂-MCE.pdfVIP

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NPS-1034(Standard)

Cat.No.:HY-100509R

CASNo.:1221713-92-3

分⼦式:C₃₁H₂₃F₂N₅O₃

分⼦量:551.54

作⽤靶点:TAMReceptor;ReferenceStandards;c-Met/HGFR;Apoptosis

作⽤通路:ProteinTyrosineKinase/RTK;Others;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NPS-1034(Standard)是NPS-1034(HY-100509)的分析标准品。本产品⽤于研究及分析应⽤。NPS-1034是

AXL和MET的双重抑制剂，其IC50值分别为10.3和48nM。

IC50TargetIC50:10.3nM(AXL),48nM(MET)[1]

REFERENCES

[1].RhoJK,etal.METandAXLinhibitorNPS-1034exertsefficacyagainstlungcancercellsresistanttoEGFRkinaseinhibitorsbecauseof

METorAXLactivation.CancerRes.2014Jan1;74(1):253-62.

[2].ShinJS,etal.NPS-1034,anovelMETinhibitor,inhibitstheactivatedMETreceptoranditsconstitutivelyactivemutants.InvestNew

Drugs.2014Jun;32(3):389-99.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.