NPS-2143-Standard-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

NPS-2143(Standard)

Cat.No.:HY-10007R

CASNo.:284035-33-2

分⼦式:C₂₄H₂₅ClN₂O₂

分⼦量:408.92

作⽤靶点:CaSR;ReferenceStandards

作⽤通路:GPCR/GProtein;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NPS-2143(Standard)是NPS-2143(HY-10007)的分析标准品。本产品⽤于研究及分析应⽤。NPS-2143(SB-

262470A)，⼝服活性溶钙剂，是选择性的钙敏感受体(CaSR)拮抗剂。NPS-2143(SB-262470A)阻断通过激活

表达⼈Ca2+受体的HEK293细胞中的Ca2+受体⽽引起的胞浆Ca2+浓度增加(IC50

IC50TargetIC50:43nM(Ca2+receptor)

REFERENCES

[1].NemethEF,etal.Calcilyticcompounds:potentandselectiveCa2+receptorantagoniststhatstimulatesecretionofparathyroid

hormone.JPharmacolExpTher.2001Oct;299(1):323-31.

[2].RybczynskaA,etal.HypertensiveeffectofcalcilyticNPS2143administrationinrats.JEndocrinol.2006Oct;191(1):189-95.

[3].OhsuT,etal.Involvementofthecalcium-sensingreceptorinhumantasteperception.JBiolChem.2010Jan8;285(2):1016-22

[4].NakajimaS,etal.Calcium-sensingreceptormediatesdietarypeptide-inducedCC