Nrf2-IN-4-hydrobromide-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

Nrf2-IN-4hydrobromide

Cat.No.:HY-175209A

分⼦式:C₂₀H₁₄BrCl₂N₅S

分⼦量:507.23

作⽤靶点:Keap1-Nrf2;Ferroptosis;ReactiveOxygenSpecies(ROS);

Atg8/LC3

作⽤通路:NF-κB;Apoptosis;Immunology/Inflammation;Metabolic

Enzyme/Protease;Autophagy

储存⽅式:Powder-20°C3years

4°C2years

Insolvent-80°C6months

-20°C1month

BIOLOGICALACTIVITY

⽣物活性Nrf2-IN-4(CompoundPhcY)hydrobromide是⼀种Nrf2抑制剂。Nrf2-IN-4hydrobromide通过抑制NRF2诱

导铁死亡(ferroptosis)。Nrf2-IN-4hydrobromide破坏细胞铁稳态，促进铁蛋⽩降解，并最终触发铁死亡。

Nrf2-IN-4hydrobromide通过促进铁依赖性活性氧(ROS)产⽣和溶酶体酸化来诱导溶酶体激活。Nrf2-IN-4

hydrobromide显⽰出显著的抗肿瘤效果。Nrf2-IN-4hydrobromide可⽤于乳腺癌研究[1]。

REFERENCES

[1].MengX,etal.Discoveryofnovelthiazolylhydrazonederivativesaspotentanti-canceragentsinducingferroptosisviadirectNRF2

inhibition.EurJMedChem.2025Jun28;297:117912.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.