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- 2026-02-06 发布于上海
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Inhibitors•ScreeningLibraries•Proteins
www.MedChemE
Odanacatib(Standard)
Cat.No.:HY-10042R
CASNo.:603139-19-1
分⼦式:C₂₅H₂₇F₄N₃O₃S
分⼦量:525.56
作⽤靶点:Cathepsin;ReferenceStandards
作⽤通路:MetabolicEnzyme/Protease;Others
储存⽅式:Pleasestoretheproductundertherecommendedconditionsin
theCertificateofAnalysis.
BIOLOGICALACTIVITY
⽣物活性Odanacatib(Standard)是Odanacatib(HY-10042)的分析标准品。本产品⽤于研究及分析应⽤。Odanacatib
(MK-0822)是有效，选择性的组织蛋⽩酶K抑制剂，IC50分别为0.2nM和1nM。
IC50TargetIC50:0.2nM(HumanCathepsinK),1nM(RabbitCathepsinK)
REFERENCES
[1].JacquesYvesGauthier,etal.Thediscoveryofodanacatib(MK-0822),aselectiveinhibitorofcathepsinK.BioorgMedChemLett.2008
Feb1;18(3):923-8.
[2].LeungP,etal.TheeffectsofthecathepsinKinhibitorodanacatibonosteoclasticboneresorptionandvesiculartrafficking.Bone.2011
Oct;49(4):623-635.
[3].NgKW.Potentialroleofodanacatibinthetreatmentofosteoporosis.ClinIntervAging.2012;7:235-47.
[4].YiC,etal.InhibitionofcathepsinKpromotesosseointegrationoftitaniumimplantsinovariectomisedrats.SciRep.2017Mar
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