OGT-2115-Standard-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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OGT2115(Standard)

Cat.No.:HY-100898R

CASNo.:853929-59-6

分⼦式:C₂₄H₁₆BrFN₂O₄

分⼦量:495.3

作⽤靶点:Glycosidase;ReferenceStandards

作⽤通路:MetabolicEnzyme/Protease;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性OGT2115(Standard)是OGT2115(HY-100898)的分析标准品。本产品⽤于研究及分析应⽤。OGT2115是⼀

种有效的，细胞可渗透且⼝服活性的⼄酰肝素酶(heparanase)抑制剂，IC50为0.4μM。OGT2115具有抗⾎

管⽣成特性(IC50为1μM)。OGT2115还抑制硫酸⼄酰肝素的降解活性。

IC50TargetIC50:0.4μM(Heparanase)[1]

REFERENCES

[1].[1]CourtneySM,etal.Furanyl-1,3-thiazol-2-ylandbenzoxazol-5-ylaceticacidderivatives:novelclassesofheparanaseinhibitor.Bioorg

MedChemLett.2005May2;15(9):2295-9.

[2].LiY,etal.Suppressionofendoplasmicreticulumstress-inducedinvasionandmigrationofbreastcancercellsthroughthe

downregulationofheparanase.IntJMolMed.2013May;31(5):1234-42.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.