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NT157(Standard)

Cat.No.:HY-100037R

CASNo.:1384426-12-3

分⼦式:C₁₆H₁₄BrNO₅S

分⼦量:412.26

作⽤靶点:InsulinReceptor;ReferenceStandards;STAT

作⽤通路:ProteinTyrosineKinase/RTK;Others;JAK/STATSignaling;

StemCell/Wnt

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性NT157(Standard)是NT157(HY-100037)的分析标准品。本产品⽤于研究及分析应⽤。NT157(Tyrphostin

NT157)是⼀种选择性的IRS-1/2抑制剂，诱导Ser磷酸化，导致IRS-1/2的降解。NT157(TyrphostinNT157)是

⼀种⾸创的抗癌药物，也可以靶向Stat3信号通路。

IC50TargetIRS-1/2[1];Stat3[2]

REFERENCES

[1].DownregulatedtheTyr-phosphorylationofIRS-1intheMG-63andU-2OScells.

[2].Flashner-AbramsonE,etal.TargetingmelanomawithNT157byblockingStat3andIGF1Rsignaling.Oncogene.2016May

19;35(20):2675-80.

[3].IbukiN,etal.ThetyrphostinNT157suppressesinsulinreceptorsubstratesandaugmentstherapeuticresponseofprostatecancer.Mol

CancerTher.2014Dec;13(12):2827-39.

[4].IshiiH,etal.miR-130aandmiR-145re