18例AchR抗体、Titin抗体阳性重症肌无力临床特点分析.pdfVIP

JOURNALOFRAREANDUNCOMMONDISEASES,JUL.2024,Vol.31,No.7,TotalNo.180

·论著·

18例AchR抗体、Titin抗体阳性重症肌无力临床特点分析

刘波*

安阳市人民医院神经内科(河南安阳455000)

目的探讨AchR抗体、Titin抗体双阳性的重症肌无力患者的临床特点。方法回顾分析AchR抗体、Titin抗体双阳性的重症肌无力病例(A组)18例，AchR抗体

【摘要】

阳性重症肌无力病例(B组)20例。通过患者性别、首次发病年龄、首发临床症状、合并相关抗体情况(ANA抗体、甲状腺抗体)、合并胸腺瘤、新斯的明结

果、RNS电生理结果、Osserman分型方面分析。结果收集38例重症肌无力患者，男21例，女17例，年龄58.29±12.99岁，其中A组男9例，女9例，年龄

60.28±9.04岁，B组男12例，女8例，年龄56.5±15.76岁。在P=0.05水平上，A、B两组组间性别、发病年龄、合并自身免疫性疾病、胸腺瘤、新斯的明

试验阳性、RNS、累及肌肉、眼睑型百分比等各项临床指标无统计学意义。结论对于AchR抗体、Titin抗体阳性和单AchR抗体阳性患者来说，从性别、

发病年龄、临床表现、胸腺瘤、合并自身免疫性疾病等方面分析，组间无差异，可认为titin抗体是伴随抗体。抗体检测对于重症肌无力诊治至关重要，分

析临床表型、免疫学特点及治疗反应性，可以促使临床医生更好的制订更针对性的治疗方案。

【关键词】重症肌无力；AchR抗体；Titin抗体；胸腺瘤

【中图分类号】R746.1

【文献标识码】A

DOI:10.3969/j.issn.1009-3257.2024.7.046

ClinicalCharacteristicsof18CaseswithAchRAntibodyandTitin

AntibodyPositiveMyastheniaGravis

*

LIUBo.

DepartmentofNeurology,AnyangPeople’sHospital,Anyang455000,HenanProvince,China

Abstract:ObjectiveToinvestigatetheclinicalcharacteristicsofmyastheniagravispatientswithAchRantibodyandTitinantibodypositive.Methods18cases

ofmyastheniagravis(groupA)and20casesofmyastheniagravis(groupB)withAchRantibodyandTitinantibodywereretrospectivelyanalyzed.

Gender,ageoffirstonset,firstclinicalsymptoms,associatedantibodies(ANAantibody,thyroidantibody),associatedthymoma,neostigmine

results,RNSelectrophysiologicalresults,andOssermantypingwereanalyzed.ResultsAtotalof38patientswithmyastheniagraviswerecollected,

including21malesand17females,aged58.29±12.99years.Therewere9malesand9femalesingroupA,aged60.28±9.04years,and12males

and8femalesingroupB,aged56.5±15.76years.AttheP=0.05level,therewasnostatisticalsignificanceingender,ageofonset,combination

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