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维普资讯
中国医学影像技术 2004年第 2O卷第 8期 ChinJMedImagingTechnol,2004,Vol20,No8
QuantitativecriteriaofMR spectroscopyinthedifferentialdiagnosis
ofprostatecancerinChina:preliminarystudy
WANGXiao—ying,ZHOULiang—ping,DINGJian—ping,LJFei—yu,
SHAN Gang—zhi,XIAOJiang-xi,JIANGXue—xiang
(DepartmentofRadiology,PekingUniversityFirstHospital,Beijing100034,China)
-[Abstract] 0bjective ToevaluatethevalueofMRspectroscopyinthedifferentialdiagnosisofprostatecancerandtoincip—
ientlydeterminethediagnosticcriteriaofprostatecancerinChinausingMRS.Methods Twenty—onecasesofprostatecancer
and23casesofBPH allprovedbypathologyofoperationorsystemicbiopsyand17casesofnormalvolunteerwerequantita—
tivelyassessedonapersextant(region)byMRS.Thelocationsofprostatecancerweremarkedbythesurgeonandenrolled
inaregion.Thecorrespondingratiosof(Cho+Cre)/CitwerecalculatedonthebasisoftheMRSmetabolicmap.Thediag—
nosticaccuracyofMRSforprostatecancerwascalculated.Results Theaverageratiosof(Cho+Cre)/Citintheperipheral
zoneofnormalprostate,cancerousandnoncancerousregionswere0.42±0.19,2.13±0.82and0.60±0.20,respectively.
Takingthehighlimitofnormalvariance( +3SD)asdiagnosticthreshold,thatis,theareaswith(Cho+Cre)/Cit~0.99
beconsideredasprostatecancer,thediagnosticsensitivity,specificityandaccuracywas96.0 ,94.7 and95.1 ,re—
spectively.Takingthepreviouslyreportedcriteriaasdiagnosticthreshold,thatis,theareaswith(Cho+Cre)/Cit~0.86be
consideredasprostatecancer,thediagnosticsensitivity,specificityandaccuracywas97.3 ,86.3 and89.4 ,respec—
tively.Therewasnostatisticallydifferencebetween thesensitivity ( = 0.207,P一 0.649),buttherewerestatistically
differencesbetweenthespecificity (X =4.563,P=0.005)andaccuracy(X 一5.950,P一0.015).Conclusion Theratioof
(Cho+Cre)/CitO.99isapref
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