乳腺癌前哨淋巴结活检假阴性原因研究新进展.pdfVIP

现代肿瘤医学 2013年o2月 第21卷第2期 MODERNONCOLOGY，Feb．2013，VOL．21，NO…02 ·437· 乳腺癌前哨淋巴结活检假阴性原因研究新进展 吕 艳 ，牛 昀。 Researchprogressonfalsenegativereasonofbreastcancersentinellymphnodebiopsy LvYan ．Niu Yun TianjinTCMUniversity，Tianjin300193，China；DepartmentofPathology，TianjinTCM Un如ers theFirstAffiliatedHo~ital，Tianjin 300193，China；BreastCancerResearchKeyLaboratoryofNationalEducationMin~try，TianjinCancerInstituteandHospital，Tianfin 300060． ina． A【bstract】Conventionalaxillarylymphnodedissection，asapartofradicalmastectomy，usuallyleadtoedema，motor andsensoryfunctionobstacle．Thesentinellymphnodebiopsy(SLNB)isakindofminimallyinvasivelymphnodebi— opsymethod，usedastheassessmentofthearmpitlymphnodemetastasis，guidingtargetedcleaningtheaxillarylymph nodes．SLNBreducecleaningscopeofaxillarylymphnode，relievepatientssequelaofaxillarylymphnodesresection， butSLNB existsacertainproportionoffalsenegativeresults，whichhinderclinicalpromotionofSLNB，themainrea— sonsare：improperselectionofSLNBindication，preoperativeneoadjuvantchemotherapy，andomitofinternalmamma— ry sentinellymphnode，unavailableofimmunohistochemicalmethod，unskilleddetectiontechnology，etc．Enhancethe knowledgeofclinical doctorsandpathological doctoraboutsentinellymphnodebiopsyandclinical guidancefunction ofaxillarylymphnodedissectionandinternalmammarylymphnodeanatomicalvariationsofunderstanding，strengthen SLNBstandardizedoperation，withtheaidofintraoperativefrozensection，jointimmunohistochemical，RT—PCR method，canreduceSLNBfalsenegativerate． 【Keywords】sentinellymphnode；axillarylymphnode；falsenegatie；breastcancer ModemOncology2013，21(02)：0437—0439 【指示性摘要】乳腺癌根治术常规进行腋窝淋巴结清扫术，往往给患者造成疼痛、水肿、运动和感觉功能障碍。 前哨淋巴结活检(sentinellymphnodebiopsy，SLNB)是一种微创的淋巴结活检方法，用前哨淋巴结评估整个腋 窝淋巴结转移情况，有针对性的指导清扫腋窝淋巴结，减小清扫范围，减轻患者腋窝淋巴结清扫后遗症 ，但是 前哨淋巴结