环状RNA 竞争性内源RNA 新成员.pdfVIP

中国细胞生物学学报 Chinese Journal of Cell Biology 2013, 35(11): 1695– 1700 DOI: 10.11844/cj cb.2013.11.0226 环状RNA: 竞争性内源RNA新成员 * * 夏 天 蒋孝明 陈晓敏 邵永富 肖丙秀 郭俊明 (宁波大学医学院生物化学与分子生物学研究所, 浙江省病理生理学技术研究重点实验室, 宁波3152 11) 摘要 环状RNA(circRNA)广泛存在于各种生物细胞中, 具有结构稳定、丰度高和组织特异 性表达等特征。最近的研究表明, 一些circRNA作为竞争性内源RNA(ceRNA)来发挥基因表达调控 的作用。circRNA利用其microRNA(miRNA)应答元件结合miRNA, 以阻断miRNA对其靶标表达的 抑制作用, 从而调控其他相关RNA 的表达水平。circRNA在基因表达调控中重要作用的发现不仅 丰富了人们对ceRNA调控网络的认识, 而且提示circRNA在药物开发和疾病诊治中具有良好的应用 前景。 关键词 环状RNA; 竞争性内源RNA; microRNA; 基因表达调控 Circular RNA: A New Member of Competing Endogenous RNAs Xia Tian, Jiang Xiaoming, Chen Xiaomin, Shao Yongfu, Xiao Bingxiu *, Guo Junming* (Department of Biochemistry and Molecular Biology, Ningbo University School of Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Ningbo 315211, China) Abstract Circular RNAs (circRNAs) are broadly found in various species’ cells. They have several characteristics including structural stability, high expression and expression in a tissue-specific manner. Recent studies have demonstrated that several circRNAs regulate gene expression acting as competing endogenous RNAs (ceRNAs). circRNAs sequester microRNAs (miRNAs) to terminate suppression of their targets and modulate the expression level of other related RNA molecules, which share the same miRNA response elements (MREs). The findings of circRNAs’ function in gene expression not only expand our understanding about ceRNA regulation network, but also indicate that circRNAs might be developed as potential drugs and used in disease diagnosis and treatment. Key words circular RNA; competing endogenous RNA; microRNA; gene ex