高危型HPV负荷量与宫颈上皮内瘤样变级别、Ki-67和P16^ink4a表达的关系及随访观察.pdfVIP

维普资讯 520 癌《症》ChineseJournalofCancer，2008，27(5)：520—524 ．I】盏床研究 · 高危型 HPV负荷量与宫颈上皮内瘤样变级别、 Ki．67和 P16；n 表达的关系及随访观察 易 为 一， 王建六 ， 李杏红 ， 魏丽惠 。 correlationsofHigh-riskHumanPapillomaviralLoadtoCervicalIntraepithelial NeoplasiaGrades．ExpressionofKi-67andP16 andFollow-up Y1wei’一，WANG Jian—LIu1，LIXing—Hong ，WEILi—Hui’ [ABSTRACT]BACKGROUND0BJECTIVE：Itiswellknownthathigh—risk humanpapillomavirus(HPV)infectionisthemajorcauseofcervicalcancer． However， the relation between cervicalcancerand high—risk HPV load is unce~ain， and there are only a smallnumber ofrepots studying the correlationbewt een high·riskHPV loadandtumormarkers．Thisstudywasto investigate the correlationsofhigh—risk HPV load to the grade of cervical intraepithelialneoplasia (CIN)，expressionofKi一67andpl6。 inthecervical lesion，andtheabnormalcytologyaftersurgery．METHODS：Theexpression OfKi一67andpl6· in8specimensofCIN I．12specimensofCIN l1．and 41specimens ofCIN … were detected by immunohistochemistry． Allthe patientsreceived high-riskHPV load detection using hybrid capture IJfHC 1．北京大学人 民医院 l1)beforeoperationandwerefollowedupafterwards．RESULTS：Thehigh— 妇科 ． riskHPV loadwaspositivelycorrelatedtotheCIN gradeand expressionof 北京 100044 Ki．67and pl6。 ；with correlation coefficientsof0．288。0．318，and 0．336。 2．北京地坛 医院