肝细胞极化的结构功能特征及在肝脏疾病时的病理表现.pdfVIP

第23 卷 第1 期 生命科学 Vol. 23, No. 1 20 11 年1 月 Chinese Bulletin of Life Sciences Jan., 20 11 文章编号：1004-0374(2011)01-0051-06 肝细胞极化的结构功能特征及在肝脏疾病时的病理表现 卫金花，曲　强﹡ ( 中国医学科学院北京协和医院基本外科，北京 100730) 摘　要：肝细胞极化的形成和维持是肝细胞发挥正常功能的保证。与简单极化上皮细胞不同，肝细胞 在肝脏血管与胆小管间形成多个极化膜面，并由紧密连接分隔。极化肝细胞膜及细胞内骨架结构与功能 复杂并有序，其分子组成及物质转运机制近年来已被逐渐认识。由于肝细胞极化与肝脏生理功能及多种 肝脏疾病时的病理改变有着密切关系，该文就目前肝细胞极化分子和细胞水平研究现状进行综述，并探 讨此领域研究发展方向。 关键词：肝细胞；极化；转运；肝病 中图分类号：Q813; R575.1 文献标识码：A Hep atocyte polarity : constitutive and functional characteristics and p athological appearance in liver diseases * WEI Jin-Hua, QU Qiang (Department of General Surgery, Peking Union Medical College, Chinese Academy of Medical Sciences, Beij ing 100730, China) Abstract: The generation and maintenance of cell polarity is vital for hepatocyte to perform normal function. Unlike the simple polarity in epithelial cells, hepatocytes are constituted of multi-polar membranes between blood vessels and bile ducts, and separated by tight j unctions. The membranes and cytoskeletons of polarized hepa- tocyte are complex both in architecture and function . The molecular components and trafficking mechanism in the cell are being explored. As hepatocyte polarity is associated with physiological function and pathological changes in the liver, this review focuses on current research of hepatocyte polarity at molecular and cellular level, and investigated further study approached. Key words: hepatocyte; polarity; traffic; liver diseases 肝脏是体内完成多种物质代谢、解毒和胆汁分 至少有两个基底侧膜和两个由复杂槽状分支网络组