原发性肝癌患者血清IL-2表达的意义.docVIP

liu_jun2013@163.com 原发性肝癌患者血清IL-2表达水平的变化及临床意义 刘俊 刘劲松1 湖北省仙桃市第一人民医院肿瘤科，433000)原发性肝癌患者显著于健康人（P0.05）（285±0.79）ng/ml及（97±1.58）ng/mlng/ml、（5.51±2.14）ng/ml，差异具有统计学意义（P＜0.05）。IL-2表达水平在肝癌肿块直径大于5 cm为（1.96±0.67）ng/ml，而在肿块直径小于5 cm的患者为（4.89±1.69）ng/ml，差异具有统计学意义（P＜0.05）。结论 原发性肝癌患者血清IL-2表达水平显著降低，并与肿瘤的大小及有无远处转移密切有关。 [关键词] 原发性肝癌; 白细胞介素-2; ELISA 【中图分类号】 R735.7 【文献标识码】 A The levels of serum IL-2 levels in patients with primary hepatocellular carcinoma Abstract: Objective To evaluate the levels of serum of IL-2 in patients with primary hepatocellular carcinoma and its clinical significance. Methods Serum IL-2 concentrations were measured by enzyme linked immunosorbent assay (ELISA). The association between serum IL-2 levels and clinic pathological features were analyzed. Results serum IL-2 levels in patients with primary hepatocellular carcinoma were significantly lower than those in healthy persons (P0.05). The expression levels of IL-2 in patients with distant metastasis and without distant metastasis were (2.46 ± 1.25) ng/ml and (5.51 ± 2.14) ng/ml, respectively. Patients with distant metastasis had significantly lower levels of IL-2 than those without distant metastasis (P0.05). The serum expression levels of IL-2 in patients with tumor size bigger than 5 cm and with tumor size smaller than 5 cm in diameter were (1.96 ± 0.67) ng/ml and (4.89 ± 1.69) ng/ml, respectively. Serum IL-2 levels in patients with tumor size bigger than 5 cm were significantly lower than those with tumor size smaller than 5 cm in diameter. Conclusion The decreased levels of serum IL-2 in patients with primary hepatocellular carcinoma are closely correlated to tumor size and clinical staging. [Key words] primary hepatocellular carcinoma; IL-2; ELISA 白细胞介素-2（interleukin-2，IL-2），又名T细胞生长因子(T cell growth factor，TCRF)主要是由活化的CD4+T细胞和CD8+T细胞产生的具有广泛生物活性的细胞因子。IL2是机体内重要的T细胞生长因子，是保障机体正常免疫功能的关键，具有多种生物学功能1-3]，包括：能够维持活性T细胞增生，LAK细胞，促进B细胞分泌抗体，促进NK细胞产生干扰素，也参与抗体反应、造血和肿瘤监视等与其他的细胞因子，如：sIL2RIL6，IL1，IL4，TNF等形成动态免疫调节网络，维持机体正