根除幽门螺杆菌对疣状胃炎的治疗作用.docVIP

根除幽门螺杆菌对疣状胃炎的治疗作用 浙江省义乌市第二人民医院消化内科322000 黄晓东 楼正亮 季峰 【摘要】 目的 探讨根除幽门螺杆菌（Helicobacterpylori.Hp）对疣状胃炎（Variociform gastritis）的治疗作用。 方法 将疣状胃炎合并Hp感染的42例患者随机分成治疗组和对照组，治疗组患者接受四联抗Hp治疗(包括雷贝拉唑钠，枸掾酸铋，呋喃唑酮，阿莫西林)，疗程2周。对照组接受硫糖铝或铝碳酸镁治疗。治疗组和对照组在接受治疗后6个月进行胃镜检查，Hp检测。 结果 治疗组和对照组各有19例和17例完成整个研究，治疗组中有17例（89.4％）患者Hp根除，其中9例（52.9％）胃粘膜疣状隆起消失，5例(29.4%)疣状隆起明显改变（数目减少或直径变小），有效率（82.3％）。对照组患者Hp无改变，仅1例（5.8%）患者疣状隆起直径变小（P0.01）。 结论 根除幽门螺杆菌对合并Hp感染的疣状胃炎有治疗作用。 【关键词】 疣状胃炎；根除；幽门螺杆菌 Therapeutic Effect of Varioliform Gastritis After Eradication of Helicobacter pylori Huangxiaodong，Louzhengliang, Department of Gastroenterology ,Seconed Hospital of Yiwu ,Yiwu(322000). Jifeng, Department of Gastroenterology, First affiliated hospital of Zhejiang University,Hangzhou 310003,China 【Abstract】 Objective To study the sffect of eradication of H.pylori on the varioliform gastritis. Mothods 42 patients with H.pylori infection and varioliform were tested by randomized and controlled trial.Patients were randomly assigned to a treatment group (n=21) which received quadruple therapy of rabeprazole, furazolidone,bismuth citrate and amoxillin,2 weeks,or to a controlled group (n=21),which received gastric mucusa(sucralfate or hydrotalcite).All patients underwent endoscopy and H.pylori examnition after 6 months. Results 19 patients in the treatment group and 17 patients in the controlled group completed the entire trial.In the treatment grou,the H.pylori infaction of 17 patients were eradicated,in the 17 patients, the verrucous raises of 9 patients(52.9%) had disappeared ,5 patients(29.4%) had changed less and smaller.In the controlled group,the verrucous raises of 1 patient(5.8%)had changed smaller and no change in the H.pylori infaction. Conclusions Eradication of H.pylori get treatment effect of varicoliform gastritis with H.pylori infaction. 【Keyword】 Varioliform gastritis； Eradication； Helicobacter pylori 疣状胃炎是一种特殊类型的慢性胃炎，又称慢性隆起糜烂性胃炎，痘疹样胃炎，是一类在临床上无特异性，但在内镜及组织形态学上有特征性改变的胃粘膜病变[1]。疣状胃炎病因未完全阐明，文献报道疣状胃炎患者幽门螺杆菌（Hp