老年高血压患者脉压及脉压指数与肾脏功能变化的相关性研究.pdfVIP

26摇 誗论著誗 摇 (总26)《中国临床医生》 2014年 第42卷 第1期 摇 老年高血压患者脉压及脉压指数与肾脏功能变化的 相关性研究 周万先,陶赟臻,赵芸芳,郑慧雅(河北省张家口市第一医院老年病科,河北 张家口075000) 摘摇 要:摇 目的摇 探讨老年高血压患者脉压及脉压指数与肾脏功能变化的关系。 方法摇 选取本院2011年2 月至2012年10月老年高血压患者147例为观察组,选取本院同期老年健康体检人员135例为对照组,检测 血压,根据公式计算脉压和脉压指数,同时检测肾功指标,分析脉压及脉压指数与肾脏功能的相关性。 结果摇 观察组舒张压、收缩压、脉压、脉压指数、尿微量白蛋白、血 茁 微球蛋白、尿素氮、血肌酐均明显高于 2 对照组;观察组肾小球滤过率明显低于对照组,差异均有显著性(P0.05)。 脉压、脉压指数、尿微量白蛋白、 血茁 微球蛋白、尿素氮、血肌酐各指标间为正相关性,肾小球滤过率与其他指标为负相关性。 结论摇 老年 2 高血压患者脉压及脉压指数与肾脏功能相关,脉压越高,脉压指数越大,肾功能指标越差。 脉压与脉压指数 可作为肾脏功能的有效监测指标。 关键词:摇 老年;高血压;脉压;脉压指数;肾脏功能 + 中图分类号: R744.5 1摇 摇 文献标识码:A摇 摇 文章编号: 1008-1089(2014)01-0026-03 doi:10.3969/ j.issn.1008-1089.2014.01.008 Clinical research of telmisartan and salvianolate in treatment for elderly secondary chronic kidney disease ZHOU Wan鄄xian,TAOYun鄄zhen,ZHAOYun鄄fang,ZHENGHui鄄ya(Geriatrics department,Thefirsthospitalof hebei zhangjiakou,zhangjiakou075000,China) Abstract:Objective To investigate clinical effect of telmisartan and salvianolate in treatment for elderly secondary chronic kidney disease. Method78 elder patients with secondary chronic kidney disease were selected in hospital fromJanuary2011to February 2012,who were randomly divided into two groups. 39 patients oral telmisartan as control group. 39 patients oraltelmisartanandinjectedsalvianolateasobservationgroup. Courseof treatmentwas 1 year. Variousclinicalindicationsandclinicalefficacywerecomparedbetweentwogroupsbeforeandaftertreatment. Result Observation group of diastolic and systolic blood pressure,pulse pressure,pulse pressure index,the urine trace albumin,blood beta 2 microglobulin,urea nitrogen,serum creatinine were significantly higher than control group;Glomerular filtration rate observation group was obviously lower than the control