大气细颗粒物(PM2,5)对心血管内皮细胞NOS的影响[J].pdfVIP

26 1 V o l. 26, N o. 1 2006 1 A cta Scientiae C ircum stantiae J an. , 2006 , , , . 2006. ( PM 2. 5 NO S [ J] . , 26 ( 1 : 142 - 145 Zhang Y H, D ing J W, Cao S, e t a l. 2006. S tudy on ox idation s tress effects of PM 2. 5 on card iovascular endothelium cells [ J] . A cta Scient iae C ircum stant iae, 26 ( 1 : 142 - 145 ( PM2. 5 ) NOS 张蕴晖, 丁佳玮, 曹 慎, 阚海东* 复旦大学公共卫生学院环境卫生教研室, 上海 200032 : : 2005080 1 : : , . PM 2. 5, 00 100502 1m gm L- 1 24 h , PM 25 NO S, iNO S cNO S. - 1 , 02 m gmL NO S iNO S, cN OS , PM 25, . , PM 2 5 iNO S , , PM 25 . : PM ; ; 2 5 : ( 2006 0 10 14204 : R992 : A Study on oxidation stress effe ts of PM25 on ardiovas ular endothelium ells * ZHANG Yunhu ,i D ING J iaw e,i CAO Shen, KAN H a idong School of Pub licH ealth, Fudan U n ivers ity, Shangh ai 200032 R e eived 12 Jun e 2005; re eived in revised form 1 A ugu st 2005; a epted 15 N ovember 2005 A bstra t: Exposure to PM 2 5 w as found to be sign if icant ly correlated w ith th e in creas ing card iovascu lar d iseasem ortality in recen t ep idem iological studies But there have had lit tle expermi en tal stud ies to explore the potent ial m echan ism of th is adverse effect of PM 25 un til now In th is study, card iovascu lar endothelium cells w ere treated by PM co llected from u rban area of Sh anghai, w ith doses of 00 1, 005, 02 and 1 m gmL- 1 P aram eters ( includ ing 25 act ivit ies of total NO S, iNO S and cNO S ref lect ing the ox idat ion stress dam age w