高胆固醇饮食引起大鼠前列腺增大.DOCVIP

临床医学论文-高胆固醇饮食引起大鼠前列腺增大 【摘要】? 目的? 观察高胆固醇膳食对鼠前列腺及其各腺叶的影响，建立高胆固醇饮食致前列腺增大的动物模型，为进一步探讨膳食结构与前列腺增生和前列腺癌发病的关系提供实验模型。方法? 高胆固醇饮食喂养SD大鼠4个月，观察饮食对前列腺总重量的变化和不同腺叶的变化。结果? 常规饮食组体重为535±75g，高胆固醇组为747±103g，两组间体重变化差异有显著性（P＜0.01），高胆固醇组大鼠前列腺重量明显增加（1850±350mg），以腹侧叶明显(1120±230mg)，统计学处理差异有显著性（P＜0.001）。结论? 高胆固醇饮食导致前列腺的体积和重量的增加，饮食结构与前列腺重量变化密切相关，提示高胆固醇饮食是前列腺疾病发生的高危因素。??? ??? 【关键词】? 胆固醇饮食? 大鼠? 前列腺? 膳食结构??? ??? High cholesterol diet increased the weight of rat prostate??????????????? 【Abstract】? Objective? To explore the possible effects of dietary fat on the prostate of SD rats. To provide a animal model that high cholesterol diet increases the shape and size of rat prostate. Methods? A total 48 Sprague-Dawley rats were used in this experiment with 24 on high cholesterol diet and the other 24 on low cholesterol fat diet fed. The feeding were carried out for 16 weeks and started when the animals were at 15 days of age. The body weight， prostate weight and the weight of different lobes were examined. Results? The experiment showed that the weight of the prostate was much more heavy in high cholesterol diet group（1850±350mg） than that in low cholesterol diet group (P＜0.001). The body weight significantly increased in high cholesterol diet group(747±103g) compared with that in low cholesterol diet group (P＜0.01 ). Conclusion? This study provided further evidence that high cholesterol fat diet lead to increasing the weight of rat prostate. Combining the epidemiology data， the dietary fat consumption is one of the important risk factor that promotes carcinogenesis of prostate cancer.??? ??? 【Key words】? cholesterol diet? rat? prostate? diet content??? ??? 流行病学调查结果表明，长期以高脂肪为主的饮食结构和生活习惯对前列腺癌的高发病率起了主要的作用［1～3］。在欧美等国家和地区，居民的饮食习惯和饮食结构以高脂肪、红色肉类和奶制品为主，而谷类、蔬菜等植物性食品的饮食消耗量相对较低，这些地区的前列腺癌的发病率处于高发水平；亚洲的膳食结构和生活习惯与此相反，前列腺癌的发病处于最低水平［4～6］。但随着生活水平的提高和饮食结构的改变，在我国发达地区［7］，前列腺癌的发病已呈明显上升趋势，严重危害老年男性的健康和寿命。目前认为，前列腺癌的发生是长期进食高危膳食的结果，故尽早明确何种膳食成分是主要的危险因子，以便采取相应的预防措施，降低前列腺癌的发病率，是目前全球关注和急待解决的难题，但目前尚无可靠的动物模型。我们在多种实验饮食饲养SD大