肺炎患儿体内甲状腺激素水平分析.DOCVIP

临床医学论文-肺炎患儿体内甲状腺激素水平分析 【关键词】? 三碘甲状腺原氨酸 　　【摘要】 目的? 观察肺炎患儿体内T 4 、T 3 、TSH水平，以指导临床制定干预及纠正措施。 方法? 选取住院肺炎患儿40例，轻度20例，重度20例。另选取22例健康儿童作为对照组。测定肺炎急性期、恢复期血清T 3 、T 4 、TSH，并与对照组比较。 结果? 与对照组比较，轻度肺炎急性期T 3 、T 4 、TSH浓度分别为（1.82±0.47）ng/ml、（99.89±26.40）ng/ml、（3.49±1.59）μIU/ml，差异无显著性（P0.05）;重度肺炎T 3 、T 4 值分别为（1.29±0.49）ng/ml、（73.35±14.15）ng/ml，比对照组低，差异有显著性（P0.05）;TSH值（2.90±1.44）μIU/ml，差异无显著性（P0.05）;恢复期T 3 、T 4 值分别为（1.87±0.38）ng/ml、（98.29±26.20）ng/ml，基本恢复正常（P0.05）。 结论? T 3 、T 4 参与了儿童肺炎的发病，而且可作为判断肺炎轻重程度及指导治疗的参考指标。???? 　　关键词? 肺炎 甲状腺素 三碘甲状腺原氨酸???? 　　The levels of thyroid hormone in childrens pneumonia?????? 【Abstract】 Objective To investigate the plasma levels of3，5，3-triiodothyronine（T 3 ），thyroxine（T 4 ），thyroid stimulating hormone（TSH）in childrens pneumonia.Methods 40patients with pneumonia were studied:20cases with common pneumonia and20cases with severe pneumonia.T 3 ，T 4 ，TSH were measured on admission and convalescent stage.22healthy children were selected as control group for the same results.Results The plasma lev-els of T 3 ，T 4 and TSH in acute stage of common pneumonia were（1.82±0.47）ng/ml，（99.89±26.40）ng/ml，（3.49±1.59）μIU/ml，and there were no significant difference compared with contrast group.T 3 ，T 4 were reduced［（1.29±0.49）ng/ml，（73.35±14.15）ng/ml，P0.05）］in acute stage of severe pneumonia;In convalescent stage，T 3 ，T 4 levels were（1.87±0.38）ng/ml，（98.29±26.20）ng/ml versus（1.84±0.41）ng/ml，（91.92±17.02）ng/ml，P0.05;TSH levels had not significant change in acute severe pneumonia（2.90±1.44）μIU/ml versus（3.74±1.85）μIU/ml，P0.05）.Conclusion The plasma levels of T 3 ，T 4 ，TSH may contribute to the pathogenesis of childrens pneumonia and they can be looked as reference indicators of common and severe pneumonia.??? 　　Key words pneumonia thyroxine triiodothyronine?????? 　　肺炎是婴幼儿时期较常见的疾病，其临床症状重，并发症多，给儿童正常的生长发育带来严重的威胁。本文拟对肺炎患儿体内三碘甲状腺原氨酸（T 3 ）、甲状腺素（T 4 ）、促甲状腺激素（TSH）变化及其与疾病严重程度的关系等情况进行探讨，以指导临床制定干预及纠正措施。 　　1 对象及方法???? 　　1.1 研究对象 选取我院2001年10月～2004年3月住院肺炎患儿40例，男22例，女18例，年龄1.5～5岁，