手性咪唑啉酮类有机催化剂催化不对称反应77435.pdfVIP

20 6 化学 进展 Vol.20 No.6 2008 6 PROGRESS IN CHEMISTRY June, 2008 手性咪唑啉酮类有机催化剂催化的不对称反应* 姚成福孙彩霞 闫少宇吴海虹* * ( 上海华东师范大学化学系绿色化学与化工过程绿色化重点实验 上海200062) 近年来, 不对称有机催化过程日趋成熟, 用于越来越多的实际应用相对于金属催化过程有机 胺催化剂具有许多潜在的优势: 相对比较稳定, 价格较低, 容易得到, 没有金属泄露到环境或产品中的风险以 及对操作环境要求不高等, 有机胺催化已被证明是实现不对称转化的有效手段手性咪唑啉酮催化剂是有 机胺催化剂中重要的 一种类型本文总结了手性咪唑啉酮催化剂在 iels-Alder 反应1, 3-偶极环加成 Michael 反应Friede-l Crafts 烷基化等不对称催化反应中的应用研究进展, 并对未来手性咪唑啉酮在工业中的 应用作了展望 有机催化不对称反应手性咪唑啉酮亚胺离子烯胺 中间体 : O62125;O64336 : A : 1005-281X(2008)06-0887-12 Chiral Imidazolidinones-Catalyzed Asymmetric Reactions * * Yao Chengf u S un Caix ia Yan Shaoy u Wu H aihong (ShanghaiKey Laboratory of Green Chemistry and Chemical Processes, Chemistry epartment of East China Normal University, Shanghai 200062, China) AbstractEnantioselective organocatalytic processes have developed maturely in recent years with an impressive number of applications now available. Aminocatalysis has proven to be a powerful procedure for the enantioselective transformations owing to their potential advantages over meta-l catalyzed processes: usually more stable, less expensive, readily available, norisk of metal leakage into environment or theproduct, and can be applied in less demanding reaction conditions. Chiral imidazolidinones is an important sort of aminocatalysts. The paper summarizes the applications and advances of chiral imidazolidinones in asymmetric catalytic reactions, such as iels-Alder reaction, 1, 3-dipolar cycloaddition, Michael reaction, Friede-l Crafts alkylation. Moreover, thefuture applications of chiral imidazolidinones in the industry manufactures are also prospected. Key words organocatalysis; asymmetricreactions; chiral imidazolidinones; iminium ions; enamine; inte