樟芝菌种于中药草固态发酵萃取液对抗人类肝癌动物试验功效研究.pdfVIP

176 海峡两岸第十届菌物学暨第三届食药菌学术研讨会 樟芝菌种于中药草固态发酵萃取液对抗人类肝癌 动物试验功效研究 陈启桢‘ 林雅慧 南台科技大学生物科技系 台湾台南 摘要：国内癌症死亡的排名，肺癌位居第一位。有鉴于此；我们建立肝癌的小鼠动物模式，以固体中药草培养樟芝菌 丝体，利用其萃取液作为肝癌的治疗，期望带来新的治疗契机。肝癌模式方面：以AC．J20中药草固态发酵所培养的樟 人类肝癌细胞(HepG2)有抑制增生(A丑ti-proliferation)的功效。 关键词：樟芝，皮下肿瘤模式，肿瘤 ontheSolidStateFermenationofAntrodia Study anditsAnti--Liver Pre-ClinicalTrial Cancer Activitythrough CHENChee．Jen·LINYa—Huei 7atwan Nan纽i DepartmentofBiotechnology,SouthernUniversity,No．1Street,YoungkangDtstriciton,7ainan71005,TAlw^N the cancelandliverc姐ceristhe Abstract：Therankof deathinTaiwanon firstandthesecond this lung one，respectively．In weset themiceanimal for of cancerandlivercancer．TheculturesofAntrodia model study up therapylung camphorata(篁。|． inoculatedonthesolidstateofChineseherbalsubstrates．TheWCle cinnamomea；Taiwanfungus mycelia camphorata)was harvestedandextracted谢th50％alcoh01．Inlivercancermodel。theextractof WaS tothe applied A．camphoratamycelia NODSCID with miceafter a result inoculatinghepatomacell(HepG2)byfeeding400mg／day(200mg／time，twiceday)．The on 14thshownthatthetunlorsizewas decreased rate to days thesurvival 70％．The obviously Q=O．0440。and prolongedup mechanismtoreducetumorvolume