质子泵抑制剂的药理及临床应用的研究.docxVIP

质子泵抑制剂的药理及临床应用的研究[摘要] 目的 通过对不同质子泵抑制剂的药理特征进行分析,找出它们之间的异同点,并比较其不同的临床疗效. 方法 选取本院60例患消化道溃疡的患者并随机分为两组,一组(对照组)予常规治疗和奥美拉唑,另一组(观察组)在常规治疗的基础上加雷贝拉唑, 从治愈有效率、Hp根除率、一年复发率和不良反应进行比较,观察并对比两组患者的临床疗效. 结果 观察组的临床疗效比对照组的临床疗效明显更加有效,且其在消化道中维持Ph值稳定的时间相对而言也较长,两组比较差异有统计学意义(p0.05). 结论 质子泵抑制剂是有效治疗消化道溃疡的药物,在临床已得到广泛的运用,随着医学技术的发展新的质子泵抑制剂和传统药物相比,由于某些药理作用的变化使得临床疗效更显著也更有效.[关键词] 质子泵抑制剂;药理;临床应用;[Abstract] Objective: By analyzing the pharmacological profile of different proton pump inhibitor(PPI), similarities and differences between them are found and their different clinical efficacy are compared. Methods: 60 patients with peptic ulcer were selected to be divided into two groups randomly. One group (control group) was received regular treatment and omeprazole and rabeprazole was added to the other group (observer group) on the basis of regular therapy. Comparing the cure efficiency, hp eradication rate, yearly recurrence rate and adverse reactions, the clinical efficacy of two groups were observed and compared. Result: the clinical efficacy of observed group was significantly more efficiently than the control group. In addition, its time of maintaining the stability of PH value in the digestive tract is comparatively longer than the control group, and the difference was statistically significant (p0.05). Conclusion: PPI is an effective treatment of peptic ulcer, and it has been largely used clinically. With the development of medical technology, new PPI makes clinical efficacy more significant and effective compared to the traditional medicines due to changes in some pharmacological effects.[Key words] PPI; pharmacodynamics; Clinical Application.随着我国社会环境和人民生活方式的变化以及越来越强的学习和工作压力,消化道溃疡的发病率正逐年上升,因其经常反复发作故给病人和其家属带来了许多不便和困扰.目前,临床上常规治疗消化道溃疡的方法包括一般治疗和药物治疗,药物治疗主要包括抗酸剂、质子泵抑制剂和抗菌治疗,其中质子泵抑制剂已成为治疗和胃酸分泌过多相关疾病的最重要的药物,在临床上得到了广泛的运用.随着医学技术的不断发展,新的质子泵抑制剂已经问世.因此，综合分析和总结不同质子泵抑制剂的药理作用及其在临床中的应用就显得非常重要，对进行一步提高消化道溃疡患者的临床疗效具有十分重要的意义.1 材料与方法一般材料 选取 2011年2 月—2013 年2月住院治疗的消化道溃疡患者60 例，采用不同的质子泵抑制剂进行治疗，其中男性患者32例，女性患者28 例，年龄 21-