肾脏原发性滑膜肉瘤4例临床病理分析.pdfVIP

228 癌《症》ChineseJoumalofCancer，2010，29(2)：228—233 临床研究 · 肾脏原发性滑膜肉瘤 4例临床病理分析 王志蕙， 王兴春 ， 薛 梅 ClinicOpathOlOgicanalysisof4casesofprimaryrenalsynovialsarcoma Zhi—HuiWang，Xing—ChunWang，MeiXue [Abstract]BackgroundandObjective： maryrenalsynovialsarcomaisrare andmightbemisdiagnosedasanOtherrenaltumOr．Thisstudydemonstrates the clinicopathologic and immunohistochemicaI features． differentiaI diagnosis， andprognosisofsuchtumors． Methods： Histologicslidesand clinicaldatawerereviewed for4patientswithprimaryrenaIsynovialsarcoma and immunohistochemicaIstaining wasperformed． Molecularanalysiswas performed on 2 casesto demonstratethe presence ofthe SYT—SSX gene fusiontranscriptsbyreversetranscriptase polymerasechain reaction (RT— PCR) Results：Thepatientswere2womenand2menagedfrOm 32tO48 years． Thetumorswere 10．0—15．0 cm in diameter， grey—whiteand solid， and hemorrhage ornecrosiswasobserved． MicrOscOpicaI1y， the tumors consisted ofmitotically active， monomorphic plump spindle cells with indistinctcellbordersgrowing inshort， intersectingfascicles． Hypocellular myxoidareasandaprominenthemangiopericytomatouspatternwerepresent in allcases．Theaveragemitoticratewas5—8mitoses／10high—powerfields． Hemorrhage and tumornecrosiswere easilyfound． Scattered smallcysts Iinedwithf