元素分析法在中药产品质量监控中的应用.pdfVIP

中国医药导报 2014年8月第 11卷第22期 窑药品检验 窑 元素分析法在中药产品质量监控中的应用 邓 攀 熊贤红 陈小荣 李 岚 程 映 江中药业股份有限公司袁江西南昌 330004 [摘要] 目的建立参灵草渊JSLCC冤口服液中元素的检测方法袁进而对JSLCC 口服液的元素分布情况进行初步探 讨袁为进一步制订该产品的元素含量质量标准探明方向遥 方法采用微波消解法对样品进行前处理袁以电感耦合 等离子体原子发射光谱法渊ICP-OES冤同时测定JSLCC 口服液中各种元素的含量遥 结果通过57种元素盲扫袁确 定了JSLCC 口服液中含有P尧Ni尧Mn尧B尧Mg尧Ca尧Sr尧Ba尧Na及 K这 10种元素袁并对其中含量较高的P尧Mg尧Ca尧Sr尧 Na及K元素进行了定量测定遥 方法学检测结果显示袁P尧Mg尧Ca尧Sr尧Na及K元素含量相对标准偏差在 1.234%~ 6.739%之间袁回收率在97.615%~108.393%范围内袁各元素检出限在0.000 015 9~0.018 265 6 mg/L之间遥 结论 本法准确度高袁重现性好袁检测限低袁可满足日常检测需要袁初步确定了JSLCC 口服液中各元素的含量分布范围遥 [关键词] ICP-OES曰元素分析法曰中药产品 [中图分类号] R286.0 [文献标识码]A [文章编号] 1673-7210渊2014冤08渊a冤-0103-04 Application of elemental analysis on the quality monitoring of traditional Chinesemedicine DENG Pan XIONG Xianhong CHENXiaorong LILan CHENG Ying Jiangzhong Pharmaceutical Co.,Ltd.,Jiangxi Province, Nanchang 330004, China [Abstract] Objective To set up the elemental analysis method of the JSLCC Oral Liquid, to understand the elements distribution features of the JSLCC Oral Liquid, in order to establish a traditional Chinese medicine quality standard of the elements content. Methods The samples were digested by microwave digestion system, and then were determined by inductivelycoupledplasma opticalemission spectrometer (ICP-OES).Results Bytotal scanof the 57 elements,the results showedtherewere 10elements in it.They were P, Ni, Mn, B, Mg, Ca, Sr, Ba, Na and K. Six of the elements as P, Mg, Ca, Sr, Na and K which were higher had been precise determination. The results showed that all the relative standard deviation (RSD) of this six elements were 1.234%-6.739%,and the coefficients of recovery were 97.615%- 108.393%.In addition, the detection limits of this six elements were 0.000