镁合金支架双重可控释放涂层的制备及药物释放性能研究.pdfVIP

· 12· 材料导报B：研究篇 镁合金支架双重可控释放涂层的制备及药物释放性能研究* 郭关卿1，范海南1，杨志强1，许鑫华1’2 (1天津大学材料科学与工程学院，天津300072；2天津大学天津市复合材料和功能化重点实验室，天津300072) 摘要 在镁合金支架材料WE42表面制备了双重可控腐蚀和药物缓释涂层，并对其药物释放性能进行了研 究。DSC研究表明紫杉醇均匀分散在PLGA体系中。药物释放实验表明，PLGA可使紫杉醇长期持续释放，突释较 弱，释放是由扩散一降解控制。随载药膜中PEG分子量和含量的增加，药物释放率增加。外层明胶涂层能有效降低 药物释放率，延长药物释放时间。 关键词 镁合金支架紫杉醇药物释放PLGA明胶 中图分类号：R318．8 文献标识码：A and ReleaseofDualControlledon PreparationDrug Coatings Stent MagnesiumAlloys GUO Hainanl，YANG Xinhual2 Meiqin91，FAN Zhiqian91，XU School of (1 ofMaterialsScienceand 300072；2 Engineering，TianjinUniversity，TianiinTianjinKeyLaboratory andFunctional 300072) Composite Materials，TianjinUniversity，Tianjin AbstractA was tocontrolreleaseandcorrosionof stent compositecoatingprepared drug magnesiumalloys materials resultsshow can inthe curvesshow WE42．7DSC that PI。GA．The paclitaxelevenlydispersed drug-release that canbe releaseina timewithlOWinitialburstreleaseamount．Thereleaseiscon— paclitaxelgradually long drug trolledthe resultsshowthatwiththeincreaseofPEGcontentmolecular by drug diffuse-degradation．The weight，the releaseincreases．Gelatinwasselectedasouter tocontrolthe release．Theresultsshowthattheout— coating paclitaxel er canredu