PI3-K抑制剂LY294002逆转P-gp介导的白血病和胃癌细胞耐药.pdfVIP

118 of 18—121 《癌症》ChineseJournalCancer，2009，28(2)：1 ·基础研究· P13一K抑制剂LY294002逆转P·gP介导的白血病 和胃癌细胞耐药 张 晔1， 曲秀娟1， 刘云鹏-， 杨向红2， 侯科佐，。 滕月娥-． 张敬东1 ReversaleffectofP13-KinhibitorLY294002on resistanceofhumanleukemiacelIIineK562／DNRand multidrug cancercellIineSGC7901／ADR gastric Ye Xiu—Juan Zhang，1 Qu，1 Liu，1Xiang—HongYang，2 Yun—Peng Ke．ZuoHou．1Yue—E and Ten91Jing—DongZhan91 and Jinosjto Objective：Phosphatjdy [Abstract]Background 1．中国医科大学附属第一医院 kinase an roleincellsurvival． B(P13一K／Akt)signalingpathwayplaysimportant 肿瘤内科． This wasto thereversaIeffectofP13．KinhibitorLY294002on study explore 辽宁沈阳11000l humanleukemia resistance(MDR)in 2．中国医科大学附属盛京医院 P—glycoprotein(P—gP)一mediatedmultidrug cel||ineK562／DNRand cancercellline 实验病理学研究室． gastric cellsweredividedinto and 辽宁沈阳“0004 simpledrug·-treatedgroups former receivedtreatmentof groups：thegroups Medical adriamycin(ADR)，vincristine(VCR)and 1．Departmentof Oncology， ‰凡rst thelatter received ofLY294002before treatment． Hospital． groups pretreatment drug ChinaMedical exclusionmethodandM