子痫前期病人瘦素、胰岛素水平测定及其与胎儿生长发育的关系_医学论文.docVIP

子痫前期病人瘦素、胰岛素水平测定及其与胎儿生长发育的关系_医学论文 子痫前期病人瘦素、胰岛素水平测定及其与胎儿生长发育的关系_医学论文 【摘要】 目的 了解子痫前期病人及其新生儿瘦素、胰岛素水平，探讨瘦素、胰岛素在子痫前期发病中的意义及其与胎儿宫内生长发育的关系。方法 采用放射免疫分析法，对30例子痫前期病人（其中轻度、重度各15例）及30例正常孕妇的血清瘦素、胰岛素水平进行测定，同时测定其新生儿脐血瘦素、胰岛素水平。结果 子痫前期病人及新生儿脐血血清瘦素及胰岛素水平明显高于对照组（F=9.048～67.360,q=2.595～16.061,0.05、0.01)；重度子痫前期病人血清瘦素与胰岛素水平呈正相关（r=0.661，0.01）；重度子痫前期病人新生儿体质量明显低于正常对照组，差异有统计学意义（F=23.705，q=2.434～5.998，0.01）；各组新生儿瘦素水平与体质量呈正相关（r=0.423～0.757，0.05、0.01）。结论 子痫前期病人血清瘦素及胰岛素水平有随病情加重逐渐增高的趋势，两者共同参与子痫前期的发病。脐血瘦素水平可以反映胎儿宫内发育情况。 【关键词】 子痫；妊娠；瘦素；胰岛素；婴儿，新生；出生体质量 　　［ABSTRACT］ObjectiveTo measure the levels of leptin and insulin in preeclampsia patients and study the effect those factors on fetal weight at birth.MethodsBy using Radioimmunoassay, the serum levels of leptin and insulin were detected in preeclampsia women (mild: 15 cases severe: 15 cases), and 30 normal pregnant women as well as in cord blood of newborns.ResultsLevels of leptin and insulin in the patients and the newborns were significantly higher than that of the normal controls (F=9.048-67.360q=2.595-16.0610.05,0.01). A positive correlation was found between the leptin and insulin levels in severe patients (r=0.661,0.01) and the body weight of their infants was dramatically lighter than those born of normal women (F=23.705,q=2.434-5.998,0.01). The level of leptin at birth was positively correlated to birth weight (r=0.423-0.7570.05, 0.01).ConclusionThe levels of leptin and insulin in preeclampsia rise with the aggravation of the disease, suggesting that these two factors are involved in pathogenesis of the disease. The concentration of leptin in cord blood reflects the intrauterine development of fetus. ［KEY WORDS］Eclampsia Pregnancy Leptin Insulin Infant, newborn Birth weight 子痫前期是妊娠期常见的并发症，是围生期母婴死亡的主要原因。瘦素是肥胖基因的蛋白产物，主要调节机体能量代谢和脂肪沉积, 也与妊娠和生理调节有密切联系。有研究显示，子痫前期病人血清瘦素水平升高［1,2］，推测瘦素可能参与子痫前期的发病。瘦素的分泌受胰岛素调节［3］，提示瘦素和胰岛素在子痫前期的发病中可能具有相关性。本研究通过测定子痫前期病人血清瘦素、胰岛素水平，探讨其在子痫前期发病中的意义。 　　1 资料与方法 　　1.1 一般资料 选择2005年1～6月在我院剖宫产分娩的孕妇及其新生儿，孕周34～40周，其中30例为子