基于LPC2478的三通道静脉麻醉输注系统设计.pdfVIP

学术论著 中国医学装备2014年9月第11卷第9期 China Medical Equipment 2014 September Vol .11 NO.9 基于LPC2478的三通道静脉麻醉输注系统设计* ①* ② ③ ① ④ ① 陈宇珂 李 爽 袁 凯 张兴安 覃健全 窦建洪 [文章编号] 1672-8270(2014)09-006-03 [中图分类号] R197.324 [文献标识码] A [摘要] 目的： 开发一种以LPC2478为控制核心的智能化三通道静脉麻醉药代动力学给药控制系 统，以实现临床静脉麻醉精确、科学地给药。方法：采用两颗ARM微控制器LPC2478作为系统控 制核心，分别完成药代动力学模型计算、直流电机驱动及外围数据采集和处理。结果：完成基于 LPC2478三通道静脉麻醉输注系统的软硬件设计，系统根据患者体重、身高和性别，运用药动学模 型实现静脉麻醉给药由粗放式向精细化、智能化给药。测试表明三通道静脉麻醉控制输注系统结构 紧凑，密闭式环境下稳定运行，临床应用异丙酚、利多卡因血药浓度测定值与目标浓度值两者有良 好的相关性，且与目标浓度的变化一致，二者之间的误差＜25%。结论：采用现代嵌入式技术通过 药代动力学模型实现对给药速率的自动控制，降低了麻醉药物不良反应，提高了用药的安全性。 [关键词] 静脉麻醉；目标控制注射；嵌入式系统；药代动力学；微控制器 DOI: 10.3969/J.ISSN.1672-8270.2014.09.003 作者简介 The design based on microcontrollers LPC2478 for target controlled infusion of three channel/CHEN Yu-ke, LI Shuang, YUAN Kai, et al// China Medical Equipment,2014,11(9):6-8. 陈宇珂,男,(1971- ), [Abstract] Objective: To develop an intelligent three-channel intravenous anesthetics target infusion 博士，副主任技师。广 system by used LPC2478 as control core, in order to realize accurate and scientific clinical intravenous 州军区广州总医院医学 anesthesia. Methods: Using two ARM microcontrollers LPC2478 as the control core, completed 工程科，从事医疗设备 pharmacokinetic model calculation, DC motor driver and peripheral data acquisition and processing. 管理及嵌入式系统研发 Results: A large number of tests show that system has high control accuracy, reliable operation, 工作。 can meet the clinical needs. Realize the software and hardware design of three-channel intravenous anesthesia infusion system based on LPC2478. According to weight, height and gender of patient, realize the intravenous anesthesia drug delivery from the extensive to refining and intelligent based on pharmacokinetic model. The tests showed that the th