MLPA结合FISH技术是一种检测早期自然流产胚胎染色体异常的高性价比技术策略.pdfVIP

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MLPA结合FISH技术是一种检测早期自然流产胚胎染色体异常的高性价比技术策略.pdf

DNA asabiomarkerin of Spermfragmentation(SDF)showsgreatpromise diagnosis and ofassisted infert.1ityprediction reproduction present formale aimedto evaluatethe ofSDF meta—analysissystematically diagnosticaccuracy andthe valueforARToutcomesafter infertility predictive intracytoplasmicsperminjection databasesweresearchedfora¨ andCNKl ficsl).ThePudMed.Embase,FMRS,CBMdisc relevant bivariate modelwas tosummarizethe publications.Themeta-analysisemployed indicesand the receiver summary diagnostic generate operator correlation testand were Spearman coe怖cient,Cochrane—QInconsistency(Isquarelassay toassessthe studies.The indiceswere Derformed heterogeneityamong pooleddiagnostic calculated arandom—effectsmodel.PublicationbiaswasexaminedtheDeeks’ byutilizing by funnel test.TheSROCcurvefromourresultindicatedanoveralI plotasymmetry pooled and of sensitivityspecificity0.80(95%CI:0.78-O.82)and in an areasunderthe of0.9211 forSDFthe of diagnosisinfertility,withAUC(the curve)value ForSDF with TUNEL exhibiteda AUCvalueof a analysissingle test,it high 0.9506,with of of 0.77(95%cI:0.74一O.80)and pooledsensitivity specificity Comet

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