酸枣仁汤对失眠症疗效及血浆褪黑素水平的影响.pdfVIP

塑经壅瘟!i焦塑：!!生!!!!望箜!鲞笙!麴 ·学术交流· 酸枣仁汤对失眠症疗效及血浆褪黑素水平的影响 王金宝 寇绍杰 赵晓锋 代娟 李艳红 【摘要】 目的探讨酸枣仁汤对失眠症的疗效及时血浆褪黑素水平的影响。方法 选用酸枣仁汤 治疗失眠症，采用匹兹堡睡眠质量指数(PSQI)量表评定睡眠状况，采用放射免疫法测定血浆褪黑素水 平，观察其治疗前后的变化，并与正常对照进行比较，统计分析分剐采用f检验、F检验和直线相关分 析。结果 治疗前患者PSQ!总分明显高于正常对照组(f一3．282，P=0．002)。治疗后患者PsQl总 分下降(t=2．37l，P=0．007)；患者组治疗前、治疗后和正常对照组血装MT水平分别为(45。81士 P一0．009)，治疗前明显低于正常对照组和治疗后MT水平；治疗前MT水平与PSQI总分、睡眠质量 因子分、入睡时间因子分分别呈负相关关系(P0．05或PO．01)。结论酸枣仁汤治疗失眠有明显 的疗效。其作用机制可能与MT水平调节有关。 【关键词】酸枣仁汤； 失眠症；褪黑素 doi：10．3969／j．issn．1009—6574．2009．04．009 of decoctionOHinsomniaanditseffecton melatoninlevelsWANGin— EfficacyZiziphiSpinosae plasma J bao，K1)UShao a1．TheSecondA Medi— fie，ZHAOXiao—Jeng。et f，iliatedHospitalofXinxiang cal 453002，China University．Xinxiang To the [Abstract]0bjectiveinvestigate of decoctiononinsomniaandit’s efficacyZiziphiSpinosae effectOn metatonin(MT)levet．Methodsdecoctionwanusedfortreatmentof plasma Spinosae Ziziphi insomnia，thewasevaluated theconcentrationof MTwasdetectedradio efficacy byPSQI，and plasma by in beforeandaftertreatment，andwithhealthvolunteers．Datawasana— immunoassaypatients compared t test，F correlation lyzedby testand scoreswere analysis．ResultsPatients’pre—treatmentPSQI sig— thannormal nificantlyhigher control(f一3．282，P一0．002)．Post—treatmentPSQlscores，however were lowerthan MT in obviously pre—treatment(f=2．371，P=0．007)．Theplasmalevels pre—trea— tedand andhealthcontrolswere post--treatedpatients 45．81士13。23(pg／m1