围术期C-反应蛋白水平与术后低蛋白血症发生的相关性探讨_临床医学论文.docVIP

围术期C-反应蛋白水平与术后低蛋白血症发生的相关性探讨_临床医学论文 围术期C-反应蛋白水平与术后低蛋白血症发生的相关性探讨_临床医学论文 作者：柳维林，丁连安，高晓明 【摘要】 目的 探讨普外科患者围术期血浆C-反应蛋白水平与术后低蛋白血症发生的相关性。方法 分析行中等程度以上手术的普外科133例患者围术期血浆C-反应蛋白及白蛋白水平，并就可能产生低蛋白血症的C-反应蛋白水平进行相关性分析。结果 术后血浆C-反应蛋白及白蛋白水平与术前比较差异有显著统计学意义(0.01)，术前血浆C-反应蛋白水平≥10 mg/L和lt;10 mg/L的患者其术后血浆白蛋白水平比较差异有统计学意义(t=-3.226，0.05);术前血浆C-反应蛋白水平与术后低蛋白血症的发生呈显著负相关(r=-0.3630，0.001)，术后血浆C-反应蛋白水平与术后低蛋白血症的发生呈显著负相关(r=-0.3470，0.001)，术前血浆C-反应蛋白水平与术前血浆白蛋白水平呈显著负相关(r=-0.4170，0.001)。结论 围术期C-反应蛋白水平与术后低蛋白血症的发生呈显著负相关，它在预测术后感染及评价病情严重程度方面具有一定的临床意义，临床外科医师应加强对围术期C-反应蛋白水平进行监测。 【关键词】 围术期;C-反应蛋白;手术;低蛋白血症 　　[Abstract] Objective To explore the relationship of perioperative C-reactive protein levels and the incidence of postoperative hypoalbuminemia.Methods Between January 2008 and December 2008，133 patients undergoing moderate-larger operations in the Department of General Surgery were enrolled.Perioperative serum C-reactive protein and serum albumin concentrations were measured and analyzed respectively，the Pearson correlation analysis was performed.Results The postoperative serum C-reactive protein and serum albumin levels，compared with preoperative above-mentioned index proved extremely significantly(0.01).The postoperative serum albumin levels between the patients with preoperative serum C-reactive protein levels≥10 mg/L and lt;10 mg/L were different(t=-3.226，0.05).In the Pearson correlation analysis，a negative correlation was found between postoperative albuminemia and preoperative serum C-reactive protein as well as postoperative serum C-reactive protein(r=-0.3630，0.001;r=-3470，0.001).A negative correlation was found with preoperative serum C-reactive protein and serum albuminemia(r=-0.4170，0.001).Conclusion Postoperative albuminemia is negatively correlated with preoperative and postoperative serum C-reactive protein，which could be used to predict postoperative infection and evaluate condition.Clinical surgeons should pay much more attention to it. 　　[Key words] perioperative period;C-reactive protein;operat