地西泮与山莨菪碱在依沙吖啶中孕引产中的应用研究_临床医学论文.docVIP

地西泮与山莨菪碱在依沙吖啶中孕引产中的应用研究_临床医学论文 地西泮与山莨菪碱在依沙吖啶中孕引产中的应用研究_临床医学论文 作者：丛培红　彭会文　陈腾云　孙君香　张桂风　王媛媛　林晓燕　张丽　　【摘要】 目的 探讨地西泮与山莨菪碱在缩短中孕引产产程、降低第二次引产和中孕取胎机会，减轻患者痛苦的作用。方法 本研究选择自2004年5月至2008年5月，在本院中孕引产妇女用药时间超过48 h，不规律性宫缩超过14 h者共133例为研究对象，按照随机设立对照组和实验组。实验组76例给予联合使用地西泮与山莨菪碱，对照组67例给予生理盐水作安慰剂。结果 用药后6 h内引产成功率：试验组为80．26%，对照组仅为17．92%，结果有显著性差异(0．01)；而两组出血超过300 ml者均为3例，无显著性差异；试验组的疼痛指标平均为5．11，显著低于对照组6．72(0．05)。结论 对于中孕引产者联合使用地西泮和山莨菪碱能够明显缩短产程，提高引产成功率，减轻疼痛。 　　【关键词】地西泮；山莨菪碱；中孕引产；缩短产程 　　 　　【Abstract】 Objective To determine the effects of diazapam and anisodamine in palliating the pain of patients by both decurtating the labour process and elevating the acheivement rate.Methods We chosed 133 women who had experienced more than 14 hours ineffective uterine contraction after introamniotic administration of rivanol from May 2004 to May 2008．Seventy-six patients were introduced diazapam and anisodamine combinantly in the experimental group,while 67 patients were given normal sodium as placebo in the control group,abiding by the trabant principle.Thereafter,the progression of the labour process,amount of vaginal bleeding was evaluated separately.Results Successful induction rate was 80．26%in the experimental group and 17．92%in the control group(0．01).There was no significant difference between the three groups as to the bleeding amount.The average index for pain was 5．11 for the experimental group which was significantly lower than that of control group 6．72(0．05).Conclusion Combination of diazapam and anisodamine during induced abortion in midterm pregnancy could significantly decurtate labour process,enhance the achievement rate and release pain. 　　【Key words】Diazapam;Anisodamine;Induced abortion in mid-term pregnancy;Decurtating the labour process 　　 　　 　　作者单位：264200山东省威海市环翠区妇幼保健院(丛培红 彭会文 陈腾云 孙君香 王媛媛 林晓燕); 威海市口腔医院(张桂风); 威海市环翠区计划生育服务站(张丽) 　　 　　中孕引产是作为避孕失败的补救措施或因胎儿畸形而行终止妊娠的方法，对妇女的身体、心理都有很大伤害。而引产失败者，采取第二种方法引产或钳取胎儿的机会明显增加，手术并发症多，对妇女的伤害更大。因此笔者在引产过程中，配合使用地西泮与山莨菪碱来缩短引产产程、减轻患者痛苦，降低引产失败率的方法具有很大的实际意义。 　　1