丹参酮ⅡA对缺血再灌注心肌EPOR表达的影响及其机制初探.pdfVIP

丹参酮IIA对缺血再灌注心肌EPOR 表达的影响及其机制初探 江西中医药高等专科学校周玉平 邮编344000 【摘要】 目的：研究丹参酮IIA对缺血再灌注损伤心肌EPOR表达的的影响及其机制。方 ：实验大鼠随机分为假手术组、模型组、丹参酮IIA组，冠脉结扎和再松开复制动物模型，计 B、TNF—Ot的表达。 心律失常评分和心肌梗死面积，免疫组化法检测心肌组织EPOR、NF—K 法算结 果：与假手术组比较，模型组EPOR、NF—K NF_K o结论：丹参 B、TNF一仅的表达显著减少(p0．01)，而EPOR的表达进一步增强(p0．01 酮IIA促进缺血再灌注心肌EPOR的表达，其机制可能与抑制NF—KB介导的炎症反应有关o B 【关键词】心肌缺血再灌注；丹参酮IIA；EPOR；NF—K TanshinonelIA the ofEPORin regulateexpression ischemia-reperfusioninjured m anditsmechanism um Zhou oftraditionalchinese Yuping(jiangxicollege medicine，344000) the ofEPORin Abstract：Objective：tostudyexpression ischemia-reperfusioninjuredmyocardium and the mechanism．Methods：Ratswere dividedintothree regulation randomly groups：shamoperation IIA animalmodelwasconducted and group，modelgroup，tanshinonegroup．Experimental byligating leftanterior the of loosening descendingcoronary．Arrhythmiascore，infarctsize，andexpressionEPOR， NF-K inthethree of Band，rNF_Or． B，TNF_仪were EPOR，NF-K compared groups．Theexpression weredeterminedimmunohistochemical of Band EPOR，NF—K by staining．Results：Theexpression TNF一仅inmodel were thanthatinsham the higher gr