马来酸氯苯那敏药物树脂复合物制备工艺研究.pdfVIP

马来酸氯苯那敏药物树脂复合物制备工艺研究 解小刚k3，张敏2，刘艳红3，邓盛齐4 【摘要】 目的：研究马来酸氯苯那敏药物树脂复合物制备工艺。方法：对静态法从离子交换树脂、药物 溶液和盐离子浓度单因素考察，动态法从床高、交换柱直径和药物溶液浓度单因素来考察对制备工艺的影响 趋势，并对2种制备工艺进行了优化。结果：静态法工艺简单，而动态法比静态法载药量高。结论：需要根据 药物树脂复合物的应用形式来选择具体方法。 [关键词]马来酸氯苯那敏；药物树脂；静态法；动态法；均匀设计；正交设计 【中图分类号】R943．41；R976 【文献标识码]A Studieson of maleate-resin preparationchlorpheniraminecomplexes XIE Xiao—gan91’3，ZHANGMin2，LIUYan．hon93，DENGSheng．qi‘ (1 YiTaiBIO—Tech Erdos Healthand Be彬ng LLC，Be历ng100085，China；2InnermongoliaHangjinqi Quarantine YiTaiPharmaceutical Station，Erdos017000，China；3Innermongolia LLC，Erdos017000，China； 4 InstituteBiotics Medicine 61005 Industry of ofSichuan，ChinaGroup，Chendu1，China) of maleate-resin [Abstract]Objective：Tochlorpheniramine prepare affecting tothestaticstatemethodwas the factorsofion resin，thesolutionand 。tendency investigatedby single exchange drug thesaltconcentration．Theinfluencefactorsontheactivestatemethodweremeasuredthe factorsofthe by single ● column columndiameterandthe concentration．Twowere static high，the drug preparations statemethodwas the oftheactivestatewas thanthe simple，butdrugloading higher prepa- rationusedwaschosen tothe of accordingcomplexdrug—resinate． state state [Keywords]ehlorpheniraminemaleate；dru