NSCLC组织中MGMT过甲基化状况和临床病理特征的关系探讨.pdfVIP

2011 1 15 1 81 : 1007- 4287( 2011) 01- 0081- 02 NSCLC MGMT 1 2 1 1 1 亢春彦 , 陶志敏 , 肖 红, 张秀芝, 薛玉仙 ( 1. , 451191; 2. ) : ( NSCLC) DNA O6- - DNA ( MGMT) 2006 3 2009 7 77 NSCLC , 20 , PCR( MSP) MGMT 26 MGMT , 33. 8% , 1 MGMT , ( P 0. 05) ; NSCLC MGMT TNM , NSCLC MGMT : ; O6- - DNA ; ; : R7342 : A Investigation onthe relationgshipbetweenthepromoterhypermethylation ofMGMTandclinicopathologic feature inNSCLC tissues KANG Chunyan, TAO Zhimin,XIAOHong, et al.(Department of pathologyHenan edical Collegef or Staff and Workers; Zhengzhou 451191, China) Abstract: bjective T investigate the relati ngship between the pr m ter hypermethylati n f MGMT gene and clinic path l gic feature in NSCLC tissues. Methods T k 77 cases f NSCLC wh were treated in Henan Chest H spital fr m March 2006 t July 2009 as research subjects, the ther 20 cases with benign lung disease as the c ntr l gr up, the methylati n specific PCR ( MSP) were used t test the methylati n status f MGMT in tw gr ups. Results 26 cases f study gr up had MGMT gene methylati n, the inci dence rate was 33. 8% , while n case f c ntr l gr up ccurred MGMT gene methylati n, the difference between gr ups was statistical ly significant ( P 0. 05) ; The pr m ter hypermethylati n f MGMT was c rrelated t the hist ry f sm king, lymph n de metastasis, TNM stage was and l w degree f tum r differati n (P 0. 05) , but n t c rrelated t patient age, gender and hist l gical type(P 0. 05) . Conclusion The pr m ter hypermethylati n f MGMT gene may take part in lung carcin ma ev lvement. Key words:N nsmall cell lung cancer; O6- methylgua