胆汁对兔胃肠平滑肌条运动影响.pdfVIP

·18 · Chin J Integr Trad West Med Dig ,Feb 2004 Vol 12 ,No. 1 胆汁对兔胃肠平滑肌条运动的影响 1 2 2 杨淑娟 　郑天珍 　瞿颂义 　　[摘要] 　目的:观察胆汁对兔离体小肠平滑肌的影响 ,并探讨其作用机制 。方法 :取兔十二指肠纵行肌条 ,安 置在各恒温灌流肌槽中 ,并用 BL310 生物技能实验系统记录十二指肠平滑肌条的收缩活动 。结果 :胆汁显著降低 兔十二指肠肌条张力 , 减小其收缩波平均振幅及收缩频率 ,并有剂量依赖关系 。结论 :胆汁对十二指肠肌条收缩活 α 动具有明显的抑制作用 ,这种抑制作用部分经由肾上腺素能 受体及前列腺素介导 ,并有壁内神经节的参与 。 　　[ 关键词] 　胃肠活动 ; 　十二指肠平滑肌条 ; 　胆汁 ; 　收缩活动 　　[ 中图分类号] 　R333 ; R3333 Effect of Bile on Isolated Gastric Muscle Strips of Rabbits YA N G S hujuan , ZHEN G Tianz hen , Q U Songyi Physiolo gy Department , Medical College of Ningbo University , Ningbo 315211 　　Abstract Objective : To study the effect of bile on contractive activity of isolated duodenum muscle strips of rabbits and its possible involved mechanism. Methods :Bile and longitudinal muscle strips of duodenum were taken out from rabbits. Each isolated muscle strip was put in a tissue chamber contain ing 5ml Krebs solution and motility of the muscle strips was recorded simultaneously with BL310 biol ogy experimental system. Results : Bile noticeably reduced the resting tension of longitudinal muscle (LM) strips of duodenum and decreased mean contractile amplitude and contractile frequency of duode num muscle strips , which was dosedependent . Conclusion :Bile had inhibitory action on the isolated α duodenum smooth muscle strips of rabbits , which was partially mediated via adrenergic receptor and related to prostaglandin and myenteric plexus. 　　Key words