葛根汤和桂枝汤对兔颈椎间盘组织IL_1_i_省略_S_TNF_TGF_mRNA表.pdfVIP

2003 11 1 4 J Chin Integr Med, Nov 2003, Vol. 1, No. 4 273 IL- 1 iNOST NFT GFmRNA 王拥军, 施 杞, 周重建, 侯宝兴, 刘 梅, 莫 文 ( , , 200032) [ ] 1( interleukin-1, IL- 1) ( induci le nitric-oxide synthase, iNOS) ( tumor necrosis factor-al- pha, T NF) (transforming grow th factor- eta, T GF) mRNA , mRNA 36 mRNA IL- 1 mRNAiNOS mRNA ( P 0. 01) ; , IL- 1mRNAiNOS mRNA (P 0. 05 0.01) ; T NFmRNA , ( P 0. 01) ; TNFmRNA , ( P 0. 01) ; , T GFmRNA ( P 0. 01) ; , T GFmRNA ( P 0.01) ; T GFmRNA IL- 1iNOS mRNA , T GF mRNA ; TNFmRNA , , IL- 1iN- OSTNF, T GF IL- 1iNOSTNFmRNA , T GFmR- NA , ; [ ] ; ; ; 1; ; ; ; , [ ] R681. 531 [ ] A [ ] 1672- 1977(2003) 04-0273-04 Regulation effects of Gegen recipe and Guizhi recipe on expression of IL- 1, iNOS, TNF, TGFmRNA in de- generated cer ical inter ertebral disk in rabbits WANG Yong-Jun, SHI Qi, ZHOU Chong-Jian, HOU Bao-Xing, LIU Mei, MO Wen ( Institute of Spinal Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China) [ ABSTRACT] Objecti e T o study the effects of Gegen Recipe and Guizhi Recipe regulating the expression of IL- 1, iNOS, T NFand T GFmRNA in degenerated interverte ral disk caused y stimulation of wind, cold and damp. Methods T hirty-six ra - its were randomly separated into six groups, viz. control group, stimulation y w ind, cold and damp group, head in low-location group, compound model group(head in low-location plus stimulation of w ind, cold and damp) , Gegen Recipe group and Guizhi Recipe group. The gene expression of IL- 1, iNOS, TNFand T GFmRNA in degenerated cervical interverte ral disks were assayed y RT-PCR. Results Compared wit h the control group, IL- 1mRNA and iNOS mRNA expression were up-regulated in