一步法制备羧甲基茯苓多糖的工艺的的研究_张金萍.pdfVIP

Nat Prod Res Dev 2006, 18: 291- 294 : 1001- 6880( 2006) 02-0291- 04 * 张金萍 , 王敬文 ( , 311400) : , ; , : ; ; ; : R28413 : A Preparation of Carboxymethyl Pachmaran in One Step * ZHANG Jin- ping , WANG Jin-w en (Research Institute of Subtropical Forestry, CAF, Fuyang Zhejiang 311400 , China) Abstract:The condition for preparation of carboxymethyl pachmaran in one- step in organic solvent m edium w as studied in this pap er Results are show ed as follow s Ethanol is the best m edium f or the reaction of carboxyl m ethylation When the concentra- tion of ethanol is 80% , there is the highest degree of sub stitution of carboxym ethyl The reaction sp eed increases as the reaction temp erature is raised ; the degree of substitution increases as reaction tim e extends If the glucose equivalent w eight and the mo- lar rate of sodium hydroxide and chloroacetic acid are prepared appropriately, the by-product , sodium carbonylcetate, w ill occur less Compared w ith other m ethods, one step method for preparation of carboxym ethyl p achmaran is easier to operate w ith a sm aller operation volume and con sum e less w ater and organic solvent m edium With this method, the degree of substitution of carboxym ethyl is high and the w ater-solubility is good w ith solubility more th an 6 g / 100 mL in water Key words: carboxymethyl pachm aran; carboxyl methylation; degree of substitution ( Poria cocos ( Schw ) Wolf ) [ 1] ,