电刺激治疗面肌痉挛的动物实验的研究.pdfVIP

电刺激治疗面肌痉挛的动物实验研究 闫立丽1张旭 王辉 朱 晓 瑾 首都医科大学 生物医学工程学院，北京100069 本论文研究了双 向高频脉冲刺激信号对面神经传导信号的阻断作用。采用在体大鼠面神经和坐骨神经进行实验， 利用中频信号引起肌肉痉挛，采用双向高频脉冲刺激信号对痉挛部位进行刺激，观察神经动作电位的幅度和肌肉的状态来研 究阻断的效果。在一定频率下，双向高频脉冲刺激信号能完全阻断神经传导，阻断阈值随阻断频率的增加而增加；当阻断幅 值为一定值时，阻断只发生在一个频率段内，低于或者高于这个频率段都可能完全没有阻断效果;而部分阻断可发生在该频 率段之前或之后的范围。本动物实验为面肌痉挛的治疗提供了更多信息。 高频电刺激；面肌痉挛；神经传导；阻断阈值 StudyofElectricalStimulationTreatmentinHemifacialSpasmUsing RatModel YANLiliZHANG XuWANG HuiZHUXiaojin CapitalMedicalUniversity,SchoolofBiomedicalEngineering,Beijing,100069,China Westudiedtheblockingeffectoffacenerveconductionsignalusedbidirectionalhighfrequency pulsestimulatorysignal.Ratsfacenerveandsciaticnervewereusedintheexperiments.First,weusedthe intermediate-frequencysignaltoarousethespasm,thenexertedbidirectionalhighfrequencypulsestimulatory signaltothenerve,theamplitudeofnerveactionpotentialandthestateofmusclewereobservedtostudythe blockingeffect.Inacertainfrequency,bidirectionalhighfrequencypulsestimulatorysignalcouldcompletely blocknerveconduction.Withanincreaseinfrequency,blockthresholdalsoincrease;Completelyblockoccur onlyinafrequencyband,theremaynotbecompletelyblockbeloworabovethefrequencyband;Partiallyblock canoccurinarangebeforeorafterthecompletelyblockfrequencyband.Blockeffectofhighfrequencyelectrical stimulationtofacenerveactionpotentialconductioncanpotentiallyprovidenewmethodsforthetreatmentof hemifacialspasm. Highfrequencyelectricalstimulation;Hemifacialspasm;Nerveconduction;Blockthreshold l断电极，与Tektr ki口f、“Z一”n． 『阻断频率，最上 ne表示没有出甄 1. L.Condu