可逆性输尿管部分梗阻动物模型建立.pdfVIP

2006 8 32 8 J iang su M ed J, A ugust 2006, V ol 32, N o . 8 749 杨关天 杨建军 姚茂银 ( P U U O) , SD 72 , PU U O , 24 , 1248 6 , ; 48 , 24 24 , 124 8 6 , ( AP D) ( V ) , ( RCT ) , ( P 00 1) , ( P 00 1) ; , A PDV , R CT , ( P 00 1) , ( P 001) , , PU U O , PU U O ; ; ; Establishment of a model of partial unilateral ureter obstruction Y ANG G ua nt ia n , YA NG J ian u n , YAO Mao yin . D epar tment of Uro logy , Aff iliated Z hongda Hospital , So uthea st University , Na n ing 2 10009, CHI NA Abstract Obj ective T o establish an ex perimental model of rever sible part ial unilateral ureter obst ruct ion( P U U O) , and investig ate the mor pho lo gical chang e cau sed by PU U O . Methods T w enty four r ats w ere sub ected to rig ht upper ureter obstruction by embedding upper half o f the ureter into ip silater al pso as, and ult rasound and patholog y examinations w ere perfo rmed at 1, 2 , 4 , and 8 w eeks after o perat ion . 48 rats w er e established PU U O and then relieved the o bstr uction by dissecting the ur eter fr om p so as gr oov e and returning its no rmal anato mical posit ion at 2 and 4 w eeks after PU U O , and ultr aso und and patholo gy ex aminatio ns w er e perfo rmed at 1, 2 , 4, and 8 w eeks after obstructio n w as relieved . Results T he collectingsystem of the o bstr ucted kidney w as dilated pr og ressively, A PD and V w er e higher, and R CT w as thinner than those o f normal co ntr ol at every inter val ( P 00 1) . Hy dr onephr osis recover ed follo w ing the r elief o f o bstr uct ion . T he earlier r elief g ains t he quicker improv ement . Conclusion Embedding upper half o f ur eter into ipsilatera l pso as pro duced severe PU U O . O bst ruct ion can be easily rev ersed by dissectin