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2003 21 4 # 355 #
#实验研究#
BMP-2 改良纤维蛋白原支架修复软骨
缺损的实验研究
朱立新, 李 奇, 林荔军, 闵少雄, 张 力
( 第一军医大学珠江医院骨科, 广东 广州510282)
= : ( bone morphogenic protein, BMP-2)
: , ,
BMP-2, ;
: , BMP-2
, 12
( P 0.01) : BMP-2
= ; ; BMP-2;
= R318 = A = 1001- 1 5X(2003) 04- 0355- 04
Study on the effect of BMP-2 on repairing articular cartilage defects by chondrocyte-improved fibrin glue
bracket in rabbits
ZH U Li-x in, LI-qi, LIN L i-j un, et al .
Dep art ment of Orthop aedics, Zhuj ian Hosp ital, First Millitary Medical University, Gun z hou 510282,
China
= Abstract Objective: To study the effect of bone morphogenic protein ( BMP-2) on reconstruction of im-
proved fibrin glue bracket to repair the defection of articular cartilage . Methods: The chondrocytes w ere seeded
on improved fibrin glue bracket, cultured in vitro with BMP-2 to construct the compound. Proliferation of the
cells on the bracket and degradation of bracket were observed. T he compound was transplanted into the rabbit
model of art icular cart ilage defection and observed at th week. Results: Improved fibrin glue bracket fitted for
t he demand of the cartilage reparation in tissue engineering. BMP-2 could accelerate the proliferation of cartilage
cells on improved fibrin glue bracket. After w eeks when the compounds were transplanted into rabbit models,
t he reparation of these compounds had the significantly difference from the control group. onclusions: BMP-2
w hich are applied to improved fibrin glue bracket can significantly accelerate the construction of compound and
reparation of articular cartilage defect ion.
= Key word chondrocyte; fibrin glue; bone morphogenic protein; growth factor
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