血清TNF,sTNF1R和IL10在急性胰腺炎中的变化和意义.pdfVIP

T NFsT NF1R IL10 刘志鹏, 邹利权, 游 斌 ( 解放军第三二四医院消化内科, 重庆400020) : 探讨肿瘤坏死因子( T NF) 抗炎细胞因子 可溶性肿瘤坏死因子受体1( sT NF1R) 白细胞介素10 ( IL10) 在急性胰腺炎中的变化及意义 对26 例轻症胰腺炎( M AP 组) 22 例重症胰腺炎( SAP 组) 患者分别于入院第 1 4714 天进行血清TNFsTNF1R 及IL10 的检测同时设立30 例健康体检者为对照组, 并对以上数据进行统计学处理 两组患者血清TNFsTNF1RIL10 水平均在第1 天达到高峰, 然后逐步下降M AP 组血清T NF水平在第7 天降至对 照组水平, SAP 组在第14 天才降至对照组水平, 而SAP 组血清TNF水平在第147 天水平远高于MAP 组(P 0.01) 两组sT NF1R 水平变化趋势 TNF相似, 但第14 天SAP 组sT NF1R 仍维持较高水平第1 天MAP 组血清IL10 水平远高于SAP 组 ( P 0.01) TNF sTNF1RIL10 均参 了急性胰腺炎的炎症反应过程, 可以作为临床预测胰腺炎严重程度的指标 : 胰腺炎; 肿瘤坏死因子; 可溶性肿瘤坏死因子受体1; 白细胞介素10 doi: 10. 3969/j. iss . 2011.05. 007 :A : 2011) Changes and significance of serum tumor necrosis factor, soluble tumor necrosis factor recepter1, interleukin10 in acute pancreatitis L iu Zhip eng , Z ou L iquan , You B in ( 324th H osp ital of P LA , Chong q ing 400020, Ch ina) Abstract: Objective To observe the cha ges a d sig ifica ce of tumor ecrosis factor( TNF) , soluble tumor ecrosis factor recepter1( sT NF1R ) , i terleuki 10( IL10) i acute pa creatitis. Methods The 26 patie ts w ith mild acute pa creat itis ( MAP group) a d 22 patie ts w ith severe acute pa creat itis( SAP group) w ere measured the degree of TNF, sTNF1R, IL10 at 1, 4, 7, 14 d by ELISA . Mea while, the 30 healthy patie ts were co t rol group. Results I both M AP group a d SAP group, serum T NF , sT NF1R, IL10 w ere approached the peak at the first day, the decreased gradually . I SAP group, serum TNFw as sig if ica t ly higher tha those i MAP group at 1, 4, 7 d(P 0. 01) . Serum T NFi M AP decreased to the level of co t rol group 7 days lat er,w hile those i SAP decreased to t he level of co trol group 14 days later. S