抗菌药物不良反应56例报告分析.docVIP

抗菌药物不良反应56例报告分析 　　[摘要] 目的 了解我院抗菌药物不良反应（ADR）的发生规律及分布情况，旨在为指导临床合理安全使用抗菌药物提供依据。方法 分析我院2011年6月～2013年6月临床科室上报的56 例抗菌药物不良反应报告，并按抗菌药物种类、名称、给药途径、ADR临床表现等进行回顾性统计分析。结果 56例抗菌药物不良反应报告中以静脉给药为主，引起ADR的抗菌药物以头孢菌素类（占41.07%）、喹诺酮类药物（占19.64%）及大环内酯类（占14.29%）居于前三位，临床表现以皮肤症状多见，其次为消化系统及神经系统等；较严重的有过敏性休克。结论 医院应加强抗菌药物ADR监测，以减少或避免ADR的发生，为临床合理安全使用抗菌药物提供参考依据。 　　[关键词] 抗菌药物；不良反应；回顾性分析 　　[中图分类号] R978.1 [文献标识码] B [文章编号] 2095-0616（2013）22-145-02 　　Retrospective analysis on 56 reports of antimicrobial drug adverse reaction 　　YANG Yong 　　Liuxin Town Health Center of Tongshan District in Xuzhou City， Xuzhou 221142，China 　　[Abstract] Objective To investigate the occurrence and distribution of antimicrobial drug adverse reaction in our hospital， in order to provide the guidance basis for the rational and safe use of antimicrobial agents in clinical. Methods 56 reports of antimicrobial drug adverse reaction from clinical departments in our hospital from June 2011 to June 2013 were analyzed， and done retrospective statistical analysis according to the antibacterial drug type， name， route of administration， ADR clinical manifestations. Results In 56 reports of antimicrobial drug adverse reaction， the intravenous administration was the main， the top three antibacterial drugs which caused adverse drug reaction were cephalosporins（accounting for 41.07%）， quinolones（accounting for 19.64%） and macrolides （accounting for 14.29%） in turn. The common clinical manifestation was skin symptoms， followed by digestive and nervous systems symptoms， and anaphylactic shock was more serious. Conclusion The antimicrobial drug adverse reaction monitoring should be strengthened in order to reduce or avoid the occurrence of adverse drug reaction and provide the reference for the rational and safe use of antimicrobial agents in clinical. 　　[Key words] Antimicrobial agents；Adverse reactions；Retrospective analysis 　　目前抗菌药物被广泛的在临床使用，关于如何正确、合理、安全地使用抗菌药物是提高临床疗效、降低药物ADR发生率以及减少或减缓细菌耐药性发生的关键[1]。本文通过对我院2011年6月～2013年6月发生的抗菌药物ADR进行分