养精胶囊治疗DAZ基因缺失所致无精子症的临床价值.pdfVIP

(40 mg, bid). The efficacy was observed after treatment for six months and the inedxes such as semen volume, seminal α-glucosidase enzyme(α-Glu), prostatic acid phosphatase(ACP), fructose in seminal plasma(Fru), gonadal hormone(FSH, LH, T, E2, PRL) were analyzed at 3 months before and after treatment . Results : 1. The totaleffective rate was 35.7% ( 10/28) in the treated group, which was significantly higher than that in the controlgroup, 10.0% (2/20, P0.05). After ICSI/PGD, in treatment group, fertilization number was 34, fertilization rate was 44.7%, 5 cases got biochemical pregnancy, biochemical pr egnancy rate was 41.7%, 3 cases got clinical pregnancy, clinical pregnancy rate was 33.3% and two of live births. While in the control group, fertilization number was 5, the fertilization rate of 35.7%, 1 case of biochemical pregnancy, biochemical pregnancy rate was 50.0%, no clinical pregnancy. 2. There are significant differences on the average age, bilateral testicular volume and serum FSH values between the effectives and non-effectives in the treatment group(P0.05).3. Yangjing capsule elevated serum FSH, LH and T levels, had no significant impact on the E2 and PRL, while testosterone undecanoate increased T levels, and suppressed LH levels by the way of the negative feedback. 4. Yangjing capsule increased semen volume and the α-Glu, Fru and ACP level in seminal plasma. Conclusion: 1. It is treatable for the patients of lower age, larger testicular volume and not too high serum FSH. 2. Yangjing capsule is an effective drug on azoospermia duo to DAZ gene delet ion. The mechanisms which may act on the hypothalamus- pituitary-gonadal axis, thus promoting the generation of sperm. 3.Yang Jing Capsule can also promote the secretory function of epididymis, seminal vesicle and prostate. 【Key