二苯乙烯苷对SAMP8鼠脑组织胆碱能及单胺类神经递质的影响_黄忠仕.pdfVIP

　　20 10 38 4 ·38 1 · · SA MP 8 ▲ 黄忠仕, 黎　昀,黄　健, 李曙波, 农　嵩 (, 533000) 　　【】　　(T S G)S A M P 8 。　6 S A M P 8 50 , 5 , S AM P8 、、T SG 、、, 10 。6 S A M R1 10 。50 , (Ch AT ) (A chE), (NE)、(DA )、5-(5-HT )。　 S A M P 8 Ch AT , A ch E , NE、DA、5-HT , (P 0.05 0.01);T SG 、C hAT , T SG A ch E (P 0.05 0.01), NE 、DA 、5- H T ,SA M P 8 , (P 0.05 0.01)。　(A ch ) , , 。 　　【】　;;; 　　:1003-1383(2010)04-0381-03　　　　　　:R 963 　　　　　　:A d oi:10.3969/j.i ssn.1003-1383.2010.04.001 Effects of TSGon cholinergic neurotransmitter and monoamine neurotransmitter in SAMP8 mices brain H UA N G Z hongshi ,L I Y un,H UAN G J ian,L I Shubo,N ON G S ong (Youj iang Med ical Col leg e f or N a ional i ies ,B aise,Guang x i 533000, China ) 　　【Abstract】　Objective　T o obse v e the effect of T SG o n choline gic neu ot ansmitte a nd mo no amine neu ot ans- mitte co ntents in SAM P8 mices b ain.Methods　50 mice of 6 month s old with S AM P 8 we e ando mized divided to 5 g oups (10 in each g o up):SA M P 8 g oup, hupe zine A co nt o l g o up, low-, mid-and high-dose g o ups of T SG .An- o the 10 mice we e assig ned to no mal cont o l g oup.Af te medication fo 50 day s, the activity of ChA T, A chE in mices b ain in each g o up we e detected by spect ophoto met y .T he N E, DA and 5-H T contents in b ain w e e de tected by H PLC.Results　T he activity of ChA T dec eased a nd the activ ity of A chE enhanced sig nificantly, and the N E, DA and 5-HT co ntents dec eased significantly in SA M P8 mices b ain compa ing with no mal g o up(P 0.05 o 0.01). In TSG-t ea tment g oup,the activity of ChA T enhanced and the activity of AchE dec eased sig nificantly, and the N E, DA and 5-H T co ntents inc ea s