尖锐湿疣组织CD1a上皮细胞钙粘素分子及其mRNA的表达和朗格汉斯细胞的电镜观察.pdfVIP

·152· 生垦鱼壅堂盘查2螋生笙箜鲞 ·生殖免疫学· 尖锐湿疣组织 CDla、上皮细胞钙粘素分子及其mRNA的表达和 朗格汉斯细胞的电镜观察① 潘永正王飞骆丹②③(东南大学附属中大医院皮肤科，南京210009) 文献标识码A 文章编号1000-484X(2009)02-0152-05 中国图书分类号R752．5+3 [摘要】 目的：研究尖锐湿疣(Condyloma 常(0．744 7±0．108 6±0．146 0．01)，E-cadherinmRNA表达(O．1733)较正常对照(O．378 cadherin表达强度之间存在正相关关系(r=0．9404，P0．05)、CDlamRNA与E-eadherinmRNA的表达呈正相关(r=0．8381， 致HPV持续性感染，IJC的减少可能与E-eadherin表达下降导致Lc在表皮内难以滞留有关。 [关键词]尖锐湿疣；朗格汉斯细胞；CDla；上皮细胞钙粘素；超微结构 The ofCDlaandE—cadherinin accuminatmntissuesandthe expression condyloma ultramicrostructureof cell Langerhans PAN Fei，LUO Yong-Zheng，WANGDan．DepartmentofDermawlogy，ZhongdaHospital，Southeast 210009，China the andfunctionof andthemolecularmecha— [Abstract]Objective：ToinvestigatecIlan咿innumber，morphologykmgedl舢cells nismsinthed8sues accuminatum．Methods：CDIa．E-caclherinweremeasured methodandFevelBeIran— ofeondyloma bystrepm砌nperoxidase PCRin26CAlesiomand10normalcontrols．UhramicrestructureofLCwasobservedtransmissionelectronic seriptase by CA numberof smallercell and Results：Intissues，the CDla+Mdecreased(10．66±11．71，P0．05)，withshortened body，less cytoden— drites．The ofCDIamRNAwas inCA 6±0．267 thatofnonllaltissues(0． expression significantlydown-regulatedlesiom(0．4061)conlpared 744 WasfaintorabsentinCA an scoreof2．36±1．41 to7．67± 4±0．3667)(P0．01)．E-cadherin tissues，with staining average compared the E-ead