肾上腺糖皮质激素与生物钟基因表达调控的相关研究进展.pdfVIP

HEREDITAS (Beijing) 2008 2 , 30(2): 135―141 ISSN 0253-9772 综 述 DOI: 10.3724/SP.J.1005.2008.00135 倪银华, 吴涛, 王露, 夏李群, 张丹萍, 傅正伟 , 310032 摘要: 由生物体内源性生物钟所产生的昼夜节律是近年来生命科学的研究热点之一。哺乳动物中的昼夜节律系 统由位于下丘脑 SCN 核内的主钟和位于多数外周细胞中的子钟组成。生物钟基因及其编码的蛋白质组成反馈 回路,维持振荡系统持续进行并与环境周期保持同步。光照和食物是生物钟重要的授时因子, 光照刺激能引起肾 上腺中基因表达变化以及糖皮质激素的分泌, 而肾上腺糖皮质激素能减缓由食物因子引起的外周生物钟时相 的移动。可见, 肾上腺糖皮质激素与生物钟有着非常密切的关系。文章综述了两者的相互影响并对今后的研究 方向做了展望。 关键词: 糖皮质激素; 肾上腺; 生物钟; 生物节律 Advances in interactions between glucocorticoid hormones and cir- cadian gene expression NI Yin-Hua, WU Tao, WANG Lu, XIA Li-Qun, ZHANG Dan-Ping, FU Zheng-Wei College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310032, China Abstract: Circadian rhythm, which is internally generated by cell autonomous biological clocks, has been greatly con- cerned in recent years. This circadian system in mammals is composed of a master pacemaker in the suprachiasmatic nu- cleus (SCN) of the hypothalamus and slave clocks in most peripheral cell types. The clock genes and their coding proteins compose the feedback loops of the circadian system. Light and food are two major Zeitgebers to synchronize circadian clocks. Light can induce clock genes expression and glucocorticoids release in the adrenal gland, while glucocorticoids can slow down the food-induced phase-shifting of peripheral circadian oscillators, suggesting that a close relationships may exist between glucocorticoids and the circadian gene expression. This article briefly reviews the recent progress in the in- teractions between them and suggests the direction of future researches. Keywords: glucocorticoid; adrenal gland; circadian clock; b