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9_硝基喜树碱脂质体的制备和大鼠肺部给药药动学.pdf

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( ) Fudan Univ J Med Sci 2007 Mar,34( 2) 273 9 张丽邢斌吴江徐白方晓玲 ( 200032) 9(9NC) , 9NC ,, HPLC ,,, HPLC 9NC 167. 6 nm, ( 91. 51 2. 63)% ( n= 3) 9NC , : t ( 3. 8 8 0. 90) h 1/2 - 1 - 1 (0 .72 0 .0 7) h, AUC0 t (2 15 .8 8 16 .4 7) g ! h ! L (95 .2 9 6 .04) g ! h ! L , M T ( 3.72 1.6 5) h ( 1. 10 0 .08) h , 9NC 9; ; ; 94 3 A Preparation of 9Nitrocamptothecin liposome and its pharmacokinetic after pulmonary delivery to rats ZHANG Lijun, XING Bin, WU Jiang, XU Bai, FANG Xiaoling ( Dep artment of Pharmaceutics, School of P harmacy, Fudan Univ ersity , Shanghai 200032, China) Abstract Purpose To prepare 9nitrocamptothecin liposomes and study the pharmacokinetic char acteristics in rats after pulmonary delivery. Methods 9nitrocamptothecin liposomes were prepared by thin film dispersionsonication method and the particle size was determined by particle sizing sys tem. The liposomes and the unloaded drug were separated by centrifugation and the entrapment effi ciency of the liposomes was studied by HPLC. The pharmacokinetic characteristics were studiedvia in tratracheal instillation administration to rats. The plasma samples were prepared with liquidliquid ex traction andthe drug plasma concentrations were analyzed by PHPLC method. Results The mean particle size of the liposomes was 167. 6nm and the entrapment efficiency was (91. 51 2. 63) % (n