软组织肉瘤的靶向治疗进展.pdfVIP

. . 中国骨与关节杂志 2015 年 1 月第 4 卷第 1 期 Chinese Journal of Bone and Joint, January 2015, Vol 4, No.1 38 . 综述 Review . 软组织肉瘤的靶向治疗进展 任志午　王国文 DOI: 10.3969/j.issn.2095-252X.2015.01.010　　中图分类号：R738.6 作者单位：300060　天津医科大学肿瘤医院骨与软组织肿瘤科 A review on the advance of individualized therapy targeting soft tissue sarcomas REN Zhi-wu, WANG Guo-wen. Department of Orthopaedic Oncology, Cancer Hospital, Tianjin Medical University, Tianjin, 300060, PRC Abstract Soft tissue sarcomas are malignant tumors derived from mesenchymal tissues and ectodermal 【 】 neural tissues, with wide distribution and multi subtypes. Traditional treatment method of soft tissue sarcomas includes surgery, radiotherapy and chemotherapy. The treatment aims to control primary tumors and prevent the transfer of tumors. At present, molecular targeted drugs obtain positive effects in the treatment of common cancers such like non- small cell lung cancer, colorectal cancer, etc. Targeted therapeutic strategies suddenly become a new field of cancer treatment. Antitumor drugs inhibit tumor growth by retarding tumor cell proliferation with the interference of tumor development and specific protein essential for the growth. Tumor-targeting drugs have fewer side effects and well tolerance. Currently, there are a variety of targeted drugs used in soft tissue sarcoma treatment. The individualized therapy provides different solutions according to the different tumor subtypes. It will be the future development trend of soft tissue sarcomas treatment. Key words Molecular targeted therapy; Antineoplastic agents; Soft tissue neoplasms; Sarcoma 【 】 【关键词】　分子靶向治疗；抗肿瘤药；软组织肿瘤；肉瘤 软组织肉瘤 ( soft tissue sarcoma，STS ) 是源于间叶组 在于降低术区局部的复发率。目前通过手术联合放疗的方 织和与其交织生长外胚层神经组织的恶性肿瘤，包括除淋 式，肢体 STS 的局部控制率可达到 80%～90%，而躯干部 巴造血组织外的非上皮组织，即纤维、脂肪、肌肉、间皮