运动和饮食因素对脑老化小鼠学习记忆能力影响的行为学观察.pdfVIP

·932· ·基础研究· 运动和饮食因素对脑老化小鼠学习记忆能力影响的行为学观察 肖忠新，云少君，贺晓娟，蒋卫，贺恺文，魏守刚 [摘要] 脑老化小鼠模型．以Morris水迷宫测试小鼠学习记忆功能。结果高脂饲料脑老化模型组与普通饲料脑老化模型限食组、普通饲 料脑老化模型加运动组、高脂饲料脑老化模型加运动组、高脂饲料正常组、普通饲料加运动组、普通饲料正常组之间学习记忆功能 的差异均有统计学意义(P0．05)；空间探索试验显示，普通饲料脑老化模型限食组与普通饲料脑老化模型组之间的差异有统计 学意义(尸0．05)。结论运动和限食可减轻脑老化小鼠学习记忆能力的下降；高脂饮食有促进脑老化的作用。 [关键词]高脂；脑老化；学习记忆；Morris水迷宫 BehaviorObservationon and ofBrain MiceIntervenedExerciseandDietXIAO LearningMemory Aging by Ability Medical School Healthand 100069， Shao-jun，HEXiao-juan，eta1．CapitalUniversityo／。Public FamilyMedicine，Beijing China Toobserve anddietOn and inmicewith in— Abstract：Objeetiveeffectsforexercise learningmemoryability eneephalonaging duced Themodelofmicewith wasmade and abili— byD-galactose(D-gaD．Methodsencephalonaging byD-gal．Thelearningmemory wasdeterminedMorriswatermaze．ResultsTherewas differencebetweenfatfeed ofmice by significant high encephalonaging ty and fatfeedand andrestrictfoodonnormalfeed feed exercise group encephalonaginggroup，normal encephalonaginggroup，high fatfeednormal feedandexercise feed exerciseeneephalonaginggroup，high group，normal group，normal restricton feed andnormalfeeden— test，therewas differencebetween foodnormal aginggroup spatialprobe significant encephalon P0．05)．ConclusionExerciseandrestrictfoodcan the and functioninthe cephalonaginggroup(all improvelearningmemory with fat