姜黄素对高脂血症兔血液流变学血小板聚集抗氧化以及纤溶系统的影响.pdfVIP

姜黄素对高脂血症兔血液流变学、血小板聚集、抗氧化以及纤溶系统 的影响  王文祥，熊晓滨，毛卫红(北京荣昌药物研究院有限公司，北京 100078) 摘要：目的 观察姜黄素对高脂血症兔血液流变学、血小板聚集、抗氧化以及纤溶系统的影响。方法 48 只新西兰兔分 为模型对照组、姜黄素(10、20 、40 mg·kg1)组、阳性对照药(血脂康32.5 mg·kg1)组和正常对照组。摄取高脂饲料2 周后， 连续 6 周高脂饲料喂养并服用姜黄素，测定每组血液流变学指标和氧自由基的变化。结果 各给药组兔的全血黏度、全 血还原黏度、红细胞刚性指数和变型指数等指标有降低趋势，且具有剂量依赖性。姜黄素对二磷酸腺苷(ADP)和胶原诱导 的血小板聚集有一定的抑制作用，能使血清SOD 水平显著提高，MDA 和t-PA 水平明显降低，对花生四稀酸诱导的血小 板聚集未见明显影响。结论 姜黄素能够改善高脂血症兔血液流变学，抑制血小板聚集，促进纤溶的活性，并具有抗氧 化作用。 关键词：姜黄素；血液流变学；血小板聚集；抗氧化；纤溶系统 中图分类号：R965.2 文献标志码：A 文章编号：1007-7693(2013)06-0598-04 Effect of Curcumin on Hemorrheology, Platelet Aggregation, Anti-oxidation and Fibrinoly System of Hyperlipidemic Rabbit WANG Wenxiang, XIONG Xiaobin, MAO Weihong(Beijing Rongchang Medicin R ＆D Institute, Beijng 100078, China) ABSTRACT: OBJECTIVE To observe the effects of curcumin on hemorrheology, platelet aggregation, anti-oxidation and fibrinoly sestem of hyperlipidemic rabbits. METHODS Forty-eight rabbits randomly divided into 6 groups which including normal control, model, curcumin(10, 20, 40 mg·kg1) and Xuezhikang(32.5 mg·kg1) groups. After 8 weeks of high-fat food and 6 weeks of treatment of curcumin, blood rheology and oxygen free radical were measured in rabbits. RESULTS Blood reduction viscosity, red cell rigidity index and deformation index of the rabbit had the tendency of decrease. Curcumin also could inhibit the platelet aggregation, which induced by ADP and collagen. The levels of rabbit serum t-PA and MDA were lower, SOD was higher in curcumin group than that in hyperlipidemia group(P0.01). CONCLUSION Curcumin can improve the hemorrheology of the hyperlipidemic rabbits. It possessed the ability of anti-oxidation and can improve the fibrinolsis system. KEY WORDS: curcumin; hemorrheology; platelet aggregation; anti-oxidation; fibrinolsis system 姜黄(Curcuna longa L.)为姜科姜黄属植物，具 原激活剂(t-